Human chemotactic cytokine
申请(专利)号： US20050133140
专利号： US7285620B2 主分类号： C07K14/52 申请权利人： PAUL D. PONATH;
SHIXIN QIN; DOUGLAS J. RINGLER; WALTER NEWMAN; CHARLES MACKAY 公开国代码： US 优先权国家： US
摘 要：
The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic
polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, useful in in vitro methods, diagnosis and/or therapy. Also provided are
methods of use of the eotaxin proteins, e.g., in the recruitment of eosinophils to a
申请日： 2005-05-19 公开公告日： 2007-10-23
分类号： C07K14/52;
C12N15/63 发明设计人： PAUL D. PONATH;
SHIXIN QIN; DOUGLAS J. RINGLER;
WALTER NEWMAN; CHARLES MACKAY
申请国代码： US
优先权： 20050519 US
13314005; 19950623 US 49409395
摘 要 附 图：
particular site or in the treatment of
allergic conditions. Human eotaxins can be used to identify inhibitors (e.g.,
antagonists) or promoters (agonists) of human eotaxin, which can be used to
selectively modulate leukocyte function, in inflammatory and autoimmune diseases, or in infections. 主权项：
1. Isolated human eotaxin or a fragment thereof, said human eotaxin comprising the amino acid sequen
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Human chemotactic cytokine
