口腔鳞癌组织中Galectin-1表达及其临床意义
魏魁杰;潘红芽;杨筱;韩伟;钟来平;张志愿
【期刊名称】《实用口腔医学杂志》 【年(卷),期】2011(027)002
【摘要】Objective: To investigate the gene transcript level and protein expression of Galectin-1 in oral squamous cell carcinoma (OSCC) and their clinical significance. Methods: The mRNA level and protein expression of Galectin-1 in OSCC of 30 cases and paracancerous tissue were detected by fluorescent quantitive real-time RT-PCR and immunohistochemistry technique respectively. The relationship between the Galectin-1 expression level and the clinicopathological parameters was analyzed by SPSS10.0 software package.Results: The Galectin-1 mRNA transcript level and protein expression in cancerous tissue increased significantly compared with that in the para-cancerous tissue( P ＜ 0.01 ). No significant correlation was found between the Galectin-1 expression and clinical status (P ＞0.05 ), such as smoking, drinking, T stage, N stage, clinical stage and pathological differential degree. Conclusion: Up regulation of mRNA level and protein expression of Galectin- 1 may be related to the tumorigenesis and development of OSCC.%目的:探讨口腔鳞癌组织中半乳糖凝集素1(Galectin-1)基因与蛋白质的表达水平及其临床意义.方法:分别采用荧光实时定量RT-PCR和免疫组织化学方法,检测Galectin-1在30 例口腔鳞癌患者的癌组织及癌旁组
口腔鳞癌组织中Galectin-1表达及其临床意义
