应用Micro CT观察洛伐他汀和秋水仙碱对CCl4致肝损伤
后小鼠骨代谢的影响
吕思敏;于琼;夏海珊;崔燎;吴铁
【期刊名称】《中国药理学通报》 【年(卷),期】2014(000)008
【摘要】Aim Toinvestigatetheinfluenceoflovas-tatin and colchicine on bone lost of mice with liver in-juryinducedbyCCl4withMicroCT.Methods Mod-el group of liver injury was established by injecting 40% of CCl4 disolved subcutaneously. Drug interven-tion groups were treated with 2 . 6 mg · kg-1 lovastatin and 0. 065 mg·kg-1 colchicine, respevtively, by in-tragastric administration daily and last for 30 days. Se-rum enzyme activities of liver injury index and the antioxidant index of liver homogenate were measured and observed. The parameters of proximal tibia were determinedbyMicroCT.Results Inmodelgroup, the AST, ALT levels in serum and MDA content in liv-er homogenate markedly increased, and SOD, GSH-Px activities in liver homogenate significantly decreased. Moreover, the parameters of BVF, TMD of the proxi-mal tibia were significantly decreased, and SMI in-creased inversely. Both lovastatin and colchicine couldnˊt prevent liver injury. Nevertheless, lovastatin had good protection effect against bone lost in mice withliverinjuryinducedbyCCl4.Conclusion The bone mass is lost in mice with liver injury induced by CCl4 , and lovastatin has good protection
应用Micro CT观察洛伐他汀和秋水仙碱对CCl4致肝损伤后小鼠骨代谢的影响
