Synthesis of Dendritic Schiff Base Ligands for Titanium Catalyzed Enantioselective HDA Rea

Synthesis of Dendritic Schiff Base Ligands for Titanium Catalyzed Enantioselective HDA Reaction

of Danishelfsky‘ s Diene with Aldehydes

吉保明;丁奎岭;孟继本

【期刊名称】《中国化学：英文版》 【年(卷),期】2003(021)007

【摘要】A new type of dendritic NOBIN derived Schiff base ligands has been synthesized and applied to titanium catalyzed hetero-Diels-Alder reaction of Danigheifsky' s diene and aldehydes, affording the corresponding 2-substituted 2,3-dihydro-4H-pyran-4-one in good yields and moderate enantioselectivities (up to 59.2% ee). It was found that the size of dendron attached to the tridentated ligands has slight impact on the enantioselectivtty of the reaction and the second generation of dendritic ligand exhibited the best enantioselectivity. 【总页数】4页(727-730)

【关键词】不对称合成;手性树枝状席夫碱配体;应用;钛催化剂;结构选择;枝晶;异狄尔斯－阿德耳反应;催化剂载体 【作者】吉保明;丁奎岭;孟继本 【

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DepartmentofChemistry,NankaiUniversity,Tianjin300071,China

StateKeyLaboratoryofOrganometallicChemistry,ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciences,Shanghai200032,China;StateK