伴有6号染色体长臂缺失的急性髓细胞白血病二例报告及
文献复习
胡晓梅;杨晓红;王洪志;刘池;胡乃平;许勇钢;刘锋;麻柔
【期刊名称】《白血病·淋巴瘤》 【年(卷),期】2008(017)003
【摘要】Objective To investigate the clinical and biologic characteristics of acute myeloid leukemia (AML) with 6q deletions (6q-). Methods Two cases of with 6q deletions (6q-) were here described, and all the AML cases with 6q- found in the literature were reviewed. Results Two cases were diagnosed with AMLMt and AML-M2, respectively. Myloloid markers were positive on the leukemia cells in both cases, none of them expressing lymphocytic antigens. The karyotype of these patients were 46,XX,del(6)(q21q25),t(4;
7)(q10;q10)[3]/46,XX,del(6)(q21q25)[2]/46,XX[25], 46,XX,del(6)(q23),t(7;11)(p15;p15)[5]/46,XX,t(7;11)'
and
(p15;p15)[9]/46,XX
[6]. Until now, 28 cases (including present 2 cases) of AML with 6q- have been documented in the world literature. Many of the AML patients with 6q -have additional chromosomal abnormalities. The breakpoints on 6q- were widely distributed from q12 to q27, mainly involved in the 6q21-23 region. Overall, the AML patients with 6q- were associated with an unfavorable clinical outcome, with a poor response to chemotherapy and a shorter duration. 6q-clone may itself confer a malignant clinical
伴有6号染色体长臂缺失的急性髓细胞白血病二例报告及文献复习
