高剂量替加环素治疗耐碳青霉烯鲍曼不动杆菌肺炎的研究
李振华;张华;高延秋
【期刊名称】《中国实用医刊》 【年(卷),期】2018(045)014
【摘要】Objective To evaluate the effect and safety of high-dose of tigecycline in the treat-ment of pneumonia caused by carbapenems-resistant acinetobacter baumannii.Methods The clinical data of 46 patients
with
pneumonia
caused
by
carbapenems-resistant
acinetobacter baumannii were retro-spectively analyzed in the Department of Respiratory Medicine and RICU of Affiliated Zhengzhou Central Hospital of Zhengzhou University from February 2016 to August 2017.All patients were treated with tige-cycline, and the patients were divided into routine-dose group ( 24 cases ) and high-dose group (22 cases).The patients in routine-dose group were given routine-dose of tigecycline ( initial dose of 100 mg, and then 50 mg each time, q12 h); the patients in high-dose group were given high-dose of tigecycline (100 mg each time, q12 h); both of the two groups were combined with cefbperazone-sulbac-tam (1 g each time, q8 h by sulbatam).The clinical efficacy,rates of bacterial clearance ,incidences of adverse drug reaction and hospitalization days were compared between the two groups.Results After treatment, the rate of clinical efficacy and the rate of bacterial clearance in high-dose group (90.9%, 72.7%) were obviously
高剂量替加环素治疗耐碳青霉烯鲍曼不动杆菌肺炎的研究
