多标志物联合检测在类风湿关节炎诊断中的应用价值

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何芳

【期刊名称】《家庭医药》【年(卷),期】2016(000)007

【摘要】目的：研究多标志物联合检测在类风湿关节炎诊断中的应用价值；方法：选择2014年7月——2015年6月在我院检查的RA患者158例，纳入实验组，选择同期在我院接受治疗的自身免疫性疾病患者110例及体检正常者190例纳入对照组，两组患者性别、年龄比较无统计学差异（p＞0.05）。检测两组类风湿因子（RF）、角蛋白抗体（AKA）、葡萄糖-6-磷酸异构酶（GPI）、环瓜氨酸多肽抗体（抗-CCP）；结果：标志物单项检测中，特异性最高为抗-CCP（90.65%），敏感性最高为RF（80.38%），阴性预测值最高为RF（88.26%），阳性预测值最高为抗-CCP（82.6%）；标志物双项联合检测中，特异性最高为AKA+抗-CCP（94.61%），敏感性最高为抗-CCP+RF（67.72%），阴性预测值最高为 RF+抗-CCP（84.89%），阳性预测值最高为 AKA+抗-CCP（84.02%）；标志物三项联合检测中，特异性最高为 GPI+AKA+抗-CCP（95.02%），敏感性最高为 GPI+RF+抗-CCP（63.92%），阴性预测值最高为 RF+GPI+抗-CCP（82.02%），阳性预测值最高为CCP+RF+GPI（86.96%）；标志物四项联合检测中，检测RA的特异性为96.74%，阴性预测值为80.74%，阳性预测值为88.74%；结论：多项标志物联合检测可准确诊断RA并判断预后，值得应用于临床。%Objective:To explore application value of multiple markers combined detection in the diagnosis of rheumatoid arthritis.Methods:From July.2014 to June.2015,158 cases of rheumatoid

arthritis were included in the experimental group,190 cases of autoimmune diseases and 110 cases of normal physical examination were included in the control group during the same period in our hospital.There was no significant difference in sex and age between the two groups.Detected the rheumatoid factor (RF), keratin antibody (aka), glucose-6-phosphate isomerase (GPI), cyclic citrul inated peptide antibody (anti CCP) in two groups. Results:The highest specificity was anti CCP (90.65%), the highest sensitivity was RF (80.38%), the negative predictive value was RF (88.26%), and the positive predictive value was anti CCP (82.6%).In joint detection of two markers,the highest specificity was AKA+ anti CCP (94.61%), the highest sensitivity was anti CCP+RF (67.72%), and the negative predictive value was RF+ anti CCP(84.89%), and the positive predictive value was AKA+ anti CCP(84.02%).In joint detection of three markers,the highest specificity was GPI+AKA+anti CCP (95.02%), the highest sensitivity was GPI+RF+anti CCP(63.92%), and the negative predictive value was RF+GPI+anti CCP(82.02%), and the positive predictive value was CCP+RF+GPI (86.96%).In joint detection of four markers,The specificity of RA was 96.74%, the negative predictive value

was

80.74%,

the

positive markers

predictive

value

was can

88.74%.Conclusions:Multiple combined detection

accurately diagnose RA and judge prognosis, it is worthy of clinical application.

【总页数】2页(34-35)

【关键词】联合检测;类风湿关节炎;诊断【作者】何芳

【作者单位】遂宁市中心医院四川遂宁 629000 【正文语种】中文【中图分类】【文献来源】