多奈哌齐联合胞磷胆碱钠治疗轻中度阿尔茨海默病临床研
究
苗海锋;马荣;吴志强;石铸;李庆军;刘玉华;陈杭军
【期刊名称】《中国实用神经疾病杂志》 【年(卷),期】2014(000)009
【摘要】目的：观察多奈哌齐联合胞磷胆碱钠对轻中度阿尔茨海默病的认知功能的影响。方法40例轻中度阿尔茨海默病分为多奈哌齐组和多奈哌齐联合胞磷胆碱钠组各20例，治疗组给予多奈哌齐联合胞磷胆碱钠，对照组给予多奈哌齐，2组均给予控制血压、血脂等常规治疗，连续服用16周。治疗前及治疗后16周分别采用简易智力状态量表（MMSE）、日常生活活动能力量表（ADL）、经颅多普勒（TCD）、副反应量表（TESS）评估患者。结果治疗前2组MMSE评分、ADL评分、RI值及TESS值比较均无显著性差异（P＞0.05），治疗组治疗后与治疗前比较，ADL评分减少，差异具有统计学意义（P＜0.05）；治疗组MMSE亚项中记忆力、注意力和计算力、回忆力、语言能力评分与治疗前比较增加，对照组记忆力、注意力和计算力、回忆力评分与治疗前比较增加，差异具有统计学意义（P＜0.05）；治疗组患者所有检测血管治疗后与治疗前比较RI值减小，血管阻力指数降低，差异具有统计学意义（P＜0.05）；对照组患者仅LMCA治疗后与治疗前比较RI减小，差异具有统计学意义（P＜0.05）；TESS评分治疗前后比较差异无统计学意义（P＞0.05）。结论多奈哌齐联合养胞磷胆碱钠可以改善轻中度阿尔茨海默病患者的日常生活活动能力、记忆力、注意力和计算力、回忆力及语言能力，增加颅脑血流量，安全性良好。%Objective To observe the effect of donepezil combined with
citicoline sodium on cognitive function of mild to moderate Alzheimer's disease. Methods Forty patients with mild to moderate Alzheimer's disease were divided into donepezil group and donepezil combined with citicoline sodium group ,respectively ,20 cases each group.The patients in the treatment group were treated with donepezil combined with citicoline sodium ,the control group were given donepezil.Two groups were given conventional treatment to control blood pressure ,blood lipid ,and two groups were administered for 16 weeks.The mini mental state scale (MMSE) ,activities of daily living scale (ADL) ,transcranial Doppler(TCD) and treatment emergent symptom scale (TESS) were estimated before treatment and after 16 weeks'treatment. Results There were no significant differences in MMSE score ,ADL score ,RI value and TESS value between the two groups before treatment (P>0.05).The patients'ADL scores decreased in the treatment group compared with before treatment ,and the difference was
significant
(P<
0.05).The
subitem
in
MMSE
,such
as
memory ,attention and computation ability ,recall ,language ability scores in the treatment group increased compared with those before treatment ;but in the control group ,only memory ,attention and computation ability ,re-call scores increased compared with before treatment ,and the difference was significant(P<0.05).The vascular resistance in-dex (RI) in all the detected vessels of the treatment group
decreased compared with that before treatment ,and the difference was significant(P<0.05).The LMCA RI value decreased compared with that before treatment in the control group ,with a sig-nificant difference(P<0.05). Patients of two groups before and after treatment showed no significant difference in TESS score (P> 0.05).Conclusion Donepezil combined with sodium can improve the activities of daily living ,memory ,attention and computation ability ,recall and language capacity in the patients with mild to moderate Alzheimer's disease ,and increase cere-bral blood flow ,and with good security. 【总页数】3页(1-3)
【关键词】多奈哌齐;阿尔茨海默病;胞磷胆碱钠;简易精神状态量表;日常生活活动能力量表
【作者】苗海锋;马荣;吴志强;石铸;李庆军;刘玉华;陈杭军
【作者单位】广东东莞市人民医院 东莞 523000;广东东莞市人民医院 东莞 523000;广东东莞市人民医院 东莞 523000;广东东莞市人民医院 东莞 523000;广东东莞市人民医院 东莞 523000;广东东莞市人民医院 东莞 523000;广东东莞市人民医院 东莞 523000 【正文语种】中文 【中图分类】R742 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-practical-nervous-diseases_thesis/0201237187223.html
多奈哌齐联合胞磷胆碱钠治疗轻中度阿尔茨海默病临床研究
