多囊卵巢综合征患者血清Orexin A水平变化及意义
宣蓉;胡红琳;方朝晖;代芳;丁璐;杜娟;王长江
【期刊名称】《安徽医科大学学报》 【年(卷),期】2014(000)002
【摘要】目的观察多囊卵巢综合征( PCOS )患者空腹血清Orexin A( OXA)水平的变化,探讨其在PCOS发生和发展中的意义。方法选取57例PCOS患者( PCOS组)和56例月经正常的健康女性(对照组)作为研究对象,按照身体质量指数( BMI)≥24 kg/m2或<24 kg/m2分别将PCOS组和对照组分为超重/肥胖( PCOS-OW/OB, Control-OW/OB)亚组和正常体重( PCOS-NW, Control-NW)亚组。检测各组血三酰甘油( TG)、胆固醇( TC)、高密度脂蛋白( HDL)、低密度脂蛋白(LDL)、空腹血糖(FBG)、餐后2 h血糖(P2hBG)、空腹胰岛素(FINS)、餐后2 h胰岛素(P2hINS)、黄体生成素(LH)、卵泡刺激素( FSH)、睾酮( T)以及血清OXA水平；测量身高、体重、腰围( WC )、臀围；并计算 BMI、腰臀比( WHR )、LH/FSH及稳态模型胰岛素抵抗指数( HOMA-IR)。结果PCOS组空腹血清OXA水平明显低于对照组( P<0.01)；PCOS和对照组中, OW/OB 亚组 OXA 水平均低于 NW 亚组( P <0.05)。 PCOS组中血清 OXA 水平与 BMI、WC、WHR、LH、LH/FSH、FBG、P2hBG、FINS、HOMA-IR 呈负相关( P <0.05或P<0.01)。校正年龄和BMI后,血清OXA水平仍与LH、LH/FSH、FBG、P2hBG、HOMA-IR呈负相关( P<0.05或P<0.01)。多元逐步回归分析显示：HOMA-IR、LH和P2hBG是影响OXA水平的重要因素。二分类Logistic回归分析提示, OXA是PCOS发生的保护因素。结论OXA可能参与了P-COS的发生和发展。%Objective To investigate the variation of
fasting serum Orexin A ( OXA) levels and their roles in pa-tients with polycystic ovarian syndrome ( PCOS ) . Methods The subjects were divided into two groups: PCOS group(n=57) and healthy control group(n=56). According to the body mass index(BMI)≥24 kg/m2 or<24 kg/m2 , both groups were divided into overweight/obese subgroup ( PCOS-OW/OB, Control-OW/OB) and normal weight subgroup( PCOS-NW, Control-NW) . Serum triglyceride( TG) , total cholesterol( TC) , high-density lipopro-tein ( HDL) , low-density lipoprotein ( LDL) ,fasting blood glucose( FBG) , fasting insulin( FINS) , postprandial 2 h insulin (P2hINS),luteinizing
hormone(LH),follicle
stimulating
hormone(FSH),testosterone(T) and OXA level were measured. Height, body mass, waist circumstance ( WC) and hip circumference were also measured. BMI, waist-hip ratio( WHR) ,LH/FSH and HOMA-IR( homeostasis model assessment of insulin resistance) were calcu-lated. Results Fasting serum OXA levels in PCOS group were significantly lower than those in controls ( P <0.01);Fasting serum OXA levels in PCOS-OW/OB were lower than those in PCOS-NW(P<0.05);Fasting ser-um OXA levels in Control-OW/OB were significantly lower than those in Control-NW ( P<0.01 ) . After age and BMI adjustment, fasting serum OXA was correlated negatively with LH,LH/FSH,FBG,P2hBG and HOMA-IR( P<0.05 or P<0.01). Multiple stepwise regression analysis showed that HOMA-IR,LH and P2hBG were the influ-encing factors of serum
OXA level. Binary logistic regression demonstrated that OXA was the protective factor of P-COS. Conclusion The decreased serum OXA level may play a very important role in the development of PCOS. 【总页数】4页(218-221)
【关键词】多囊卵巢综合征;Orexin A;肥胖;胰岛素抵抗 【作者】宣蓉;胡红琳;方朝晖;代芳;丁璐;杜娟;王长江
【作者单位】安徽医科大学第一附属医院内分泌科，合肥 230022;安徽医科大学第一附属医院内分泌科，合肥 230022;安徽中医药大学第一附属医院内分泌科，合肥 230038;安徽医科大学第一附属医院内分泌科，合肥 230022;安徽医科大学第一附属医院内分泌科，合肥 230022;安徽医科大学第一附属医院内分泌科，合肥 230022;安徽医科大学第一附属医院内分泌科，合肥 230022 【正文语种】中文 【中图分类】R711.75 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_acta-universitatis-medicinalis-anhui_thesis/0201243333163.html 【相关文献】
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多囊卵巢综合征患者血清Orexin A水平变化及意义
