AFP-IgM复合物在肝癌中的表达与临床关系
蒋敬庭;李敏;徐斌;郑晓;刘检;石亮荣;Ning Xu;Peter Nilsson-Ehle;吴昌平;吴骏;秦锡虎;孙达成;季枚;邓海峰;陆明洋;周国平
【期刊名称】《中华肝胆外科杂志》 【年(卷),期】2009(015)008
【摘要】Objective To determine the contents of the new tumor marker alpha fetoprotein immunoglobulin M immunocomplex (AFP-IgM) in hepatocellular carcinoma (HCC) and evaluate the correlation between the level of AFP-IgM and clinical feature of HCC.Methods The contents of AFP-IgM and AFP in serum of 103 healthy subjects,74 patients with HCC,43,patients with hepatic cirrhosis and 58 patients with adiposis hepatica were detected by enzyme linked immunosorbent assay and electrochemiluminescence.Results As the critical value of diagnostic significance,the best cutoff value of AFP-IgM and AFP was 300 Au/ml and 10 ug/L,respectively.Under the cutoff value,the mean serum concentrations of AFP-IgM and AFP were significantly higher in the HCC group than in the adiposis hepatica and health examination groups (P<0.05).However,for early diagnosis of liver cancer (stage Ⅰ andⅡ),the area under ROC curve of AFP-IgM was larger than that of AFP (0.91 vs 0.82).The differences of AFP-IgM and AFP for early diagnosis of liver cancer were statistically significant.When the tumor was less than and over
3cm
in
diameter,the
contents
of
AFP-IgM
was
AFP-IgM复合物在肝癌中的表达与临床关系
