供者使用粒系集落刺激因子后供髓对异基因骨髓移植受者
的影响
纪树荃;陈惠仁;王恒湘;朱玲;薛梅;刘静;琚新生
【期刊名称】《中华器官移植杂志》 【年(卷),期】2000(021)004
【摘要】Objectives In order to investigate the influence of donor marrow stimulated with lenograstim(G-CSF) on hemotopoietic reconstitution and incidence of GVHD in the patients undergoing allogeneic bone marrow transplantation(Allo-BMT).Methods Forty-five leukemia patients as recipients underwent Allo-BMT with the bone marrow from the donors with matching HLA and negative mixed lymdays prior to marrow harvest.And 15 donors as control group did not receive G-CSF.The effects of G-CSF on hemotopoietic reconstitution and incidence of GVHD following Allo-BMT were compared between the two groups.Results In the equal volume of bone marrow harvested.the number of mononuclear cells,CFU-GM and CD34 cells in the experimental group were higher than in the control group(P＜0.01).In the experimental group, the time of granulocyte count exceeding
0.5×109/L
and
plalete
count
exceeding
20×109/Lwas(16.7±3.2)daysand(18.4±3.0)days respectively,significantly shorter
than
in
the
control
group
(22.5±5.1)days
and(26.3±5.9)days,respectively)(P＜0.01).The incidence of grade ⅡⅣ
供者使用粒系集落刺激因子后供髓对异基因骨髓移植受者的影响
