多囊卵巢综合征基础血清皮质醇水平及其昼夜规律变化
古芳;徐艳文;苗本郁;朱莉;王彬;周灿权
【期刊名称】《中国实用妇科与产科杂志》 【年(卷),期】2012(028)004
【摘要】Objective To investigate the basal cortisol level and its circadian rhythm in a cohort of Chinese women with polycystic ovary syndrome (PCOS). Methods A cohort of 63 PCOS women (21 obese and 42 non-obese) and 38 non-obese healthy controls were included in this study. Serum cortisol levels at 8AM and 4PM as well as the rate of loss of cortisol circadian rhythm were compared among the obese PCOS group, non-obese PCOS group and healthy controls. Possible factors associated with the basal cortisol level were analyzed. Results Basal cortisol level in the obese PCOS group, non-obese PCOS group and healthy controls were (325.7 ± 125. 7) nmol/L, (407. 6 ± 165. 6) nmol/L and (397.4 ±129.9) nmol/L, respectively. Obese PCOS group had a lower basal cortisol level than the healthy controls ( P < 0. 05). The ratio of 4PM: 8AM cortisol was higher in the obese(0. 78 ±0. 54) and non-obese PCOS group (0. 61 ±0. 34)than the healthy controls(0. 46 ±0. 20) (P<0. 05). Circadian rhythm loss occurred more frequently in obese PCOS patients (47.6%) than the healthy controls ( 10. 5% ) ( P < 0. 05 ) . Basal cortisol levels were inversely associated with BMI ( P < 0. 05 ). Conclusion Obese PCOS patients have an activated HPA axis,with
多囊卵巢综合征基础血清皮质醇水平及其昼夜规律变化
