The Different Expression Pattern of E-cadherin and β-catenin in Primary Nasopharyngeal Ca

The Different Expression Pattern of E-cadherin and β-catenin in Primary Nasopharyngeal Carcinoma

and Its Metastases

LIZhi;LINSuxia;LIANGHuizhen

【期刊名称】《中德临床肿瘤学杂志：英文版》 【年(卷),期】2004(003)003

【摘要】To detect the differences in the expression levels of protein and mRNA of E-cadherin and β-eatenin in primary tumor and lymph node metastatic tumor of nasopharyngeal carcinoma (NPC), and to investigate the mechanism of invasion and metastasis of neoplastic cell in NPC. Methods: 21 biopsies taken from primary tumor and another 21 biopsies from lymph node metastatic tumor of NPC were collected from the affiliated hospitals of Sun Yat-sen University of Medical Sciences during 1999 2002. Western blotting assay, immunohistoehemieal staining and reverse transeriptase-polymeraes chain reaction (RT-PCR) were adopted to detect the expression levels of protein and mRNA of E-eadherin and β-eatenin in all of 42 samples. Results: (1) In 21 eases of lymph node metastatic tumor, the protein expression level of E-eadherin was lower detected by immunohistoehemieal staining (50% in average) and Western blotting (Rh 65±15.9 in average) than that in primary tumor of NPC (80% and 206.7+32.7 in average respectively). Furthermore, mRNA expression level of E-eadherin was also lower in

metastatic tumor than that in primary tumor, with the difference being significant (P<0.05). (2) Both primary NPC and lymph node metastatic NPC were found to have high β-eatenin protein and mRNA expression with the differences being not statistically significant (P>0.05). (3) There was no correlation between neoplastic cell expression of β-eatenin and E-eadherin either in primary tumor or in lymph node metastatic tumors. Conclusion: Down-regulation of the expression of E-eadherin may play a critical role in neoplastic cell invasion and metastasis in NPC. 【总页数】6页(P.156-160,194)

【关键词】基因表达;E-钙粘素;β-链;初级保健;鼻咽癌;移位变化;肿瘤 【作者】LIZhi;LINSuxia;LIANGHuizhen

【作者单位】DepartmentofPathology,SunYat-senMedicalCollege,SunYat-senUniversity,Guangzhou510089,China 【正文语种】英文 【中图分类】R739.6 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_sino-german-journal-clinical-oncology-english_thesis/0201268925919.html 【相关文献】

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