非小细胞肺癌患者血清中胰岛素样生长因子-1水平的变化
梁伟娟;叶静;唐静;梁克;黄杰;苏敏
【期刊名称】《中华实验外科杂志》 【年(卷),期】2014(031)010
【摘要】目的 探讨非小细胞肺癌(NSCLC)患者血清中胰岛素样生长因子-1(IGF-1)的表达水平及其在NSCLC疗效评价中的临床价值.方法 采用放射免疫分析法(RIA法)检测63例NSCLC患者及32例健康体检者血清IGF-1水平,并比较44例NSCLC患者手术前后血清IGF-1水平.结果 血清IGF-1水平与NSCLC患者性别、年龄、病理类型无明显相关,与临床分期明显相关;NSCLC患者血清IGF-1水平为(258.22±52.49) μg/L明显高于健康查体者[(155.04 ±21.37) μg/L],两者差异有统计学意义(P＜0.01);Ⅳ期NSCLC血清IGF-1水平[(322.0S ±27.46) μg/L]明显高于Ⅲ期患者[(2S0.42 ±26.12) μg/L]、Ⅲ期患者明显高于Ⅱ期[(241.59 ±22.84) μg/L]、Ⅱ期患者明显高于Ⅰ期患者[(195.20±19.27) μg/L]、Ⅰ期明显高于正常对照组,两两比较差异有统计学意义(P＜0.05);NSCLC患者手术后血清IGF-1水平[(59.17 ±6.06) μg/L]明显低于手术前[(59.17 ±6.06) μg/L],两者差异有统计学意义(P＜0.01).结论 血清IGF-1可作为NSCLC病情及疗效评估的参考指标.%Objective To explore the serum expression of insulin like growth factor-1 (IGF-1) in patients with non-small cell lung cancer (NSCLC) and its clinical significance in the evaluation of treatment outcome.Methods The level of serum IGF-1 was measured by radioimmunoassay (RIA) in 32 cases of normal control subjects and 63 cases of NSCLC,and compared in 44 patients with NSCLC before and
非小细胞肺癌患者血清中胰岛素样生长因子-1水平的变化
