DOG1蛋白在胃肠道间质瘤中的表达及相关性分析

DOG1蛋白在胃肠道间质瘤中的表达及相关性分析

甄丽影;李岩;徐灿

【期刊名称】《中华消化杂志》 【年(卷),期】2010(030)009

【摘要】目的 分析DOG1蛋白与胃肠道间质瘤(GIST)的相关性.方法 收集2005年1月至2010年6月77例GIST患者,应用免疫组化法检测GIST中DOG1蛋白的表达,并结合原有免疫组化指标CD117、CD34的检测结果进行对照分析.结果 77例GIST患者中,DOG1蛋白和CD117的阳性表达率分别为96.1%(74/77)和90.9%(70/77),两组间差异无统计学意义(P＞0.05).不同性别、年龄组、病变部位及危险度间DOG1蛋白阳性表达率差异亦无统计学意义(P值均＞0.05).7例CD117阴性表达的GIST患者中6例DOG1蛋白阳性表达.3例DOG1蛋白阴性表达的GIST中2例CD117阳性表达.结论 DOG1蛋白作为一种新的GIST标志物,具有与CD117同样的高敏感性,与CD117联用于GIST诊断互补性较好,尤其对CD117阴性的GlST诊断价值优势较大,但不能作为划分GIST危险度的指标.%Objective To analyze the association of DOG1 protein with gastrointestinal stromal tumors(GIST). Methods Seventy-seven patients diagnosed with GIST between January 2005 and June 2010 were enrolled. The DOG1 expression in GIST was determined using immunohistochemistry.The result was compared with that of CD117 and CD34. Results Of 77 GIST patients, the DOG1 was expressed in 74 (96.10%) patients and CD117 in 70 (90. 9%) patients, with no significant difference between DOG1 and CD117 (P＞0.05). DOG1 expression was

not related to the risk stratification of the tumor, site, age and gender (P＞0. 05). Of 7 GIST patients with negative CD117,6 patients were positive for DOG1 expression. Whereas 2 of 3 DOG1 negative patients were positive for CD117 expression. Conclusions DOG1, as a novel marker for GIST,has high sensitivity as CD117. It is a good complementarity in diagnosis of GIST when combine DOG1 with CD117, especially in diagnosis of CD117 negative patients. However, the DOG1 can not be used as an index in eveluating the risk stratification of the GIST.

【总页数】3页(585-587)

【关键词】胃肠道间质瘤;ANO1蛋白,人类;诊断 【作者】甄丽影;李岩;徐灿

【作者单位】沈阳市第七人民医院消化科;110004,沈阳,中国医科大学附属盛京医院消化科;110004,沈阳,中国医科大学附属盛京医院病理科 【正文语种】中文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-digestion_thesis/0201232735256.html 【相关文献】

1.DOG1、CD117和Ki67在胃肠道间质瘤中的表达及其与临床病理因素和危险度的相关性 [J], 曾祥; 李岩; 裴冬梅

2.DOG1蛋白在胃肠道间质瘤中的表达意义及其与CD117表达的关系 [J], 李宝江; 姜忠敏; 张立东; 郑末; 张亮; 孙雅静; 王守峰

3.survivin在胃肠道间质瘤中的表达及其与COX-2表达的相关性 [J], 姚大鹏; 彭贵勇; 孙永刚; 石菲

4.胃肠道间质瘤中Maspin表达及其与p53表达的相关性 [J], 李宝江; 姜忠敏; 张立东; 张亮; 郑末

5.Survivin在胃肠道间质瘤中的表达及其与VEGF表达的相关性 [J], 姚大鹏; 彭责勇; 孙永刚; 石菲

以上内容为文献基本信息，获取文献全文请下载