血脂与纤维蛋白原Bβ链基因多态性的关系及对其功能表达
的影响
王淑娟;元小冬;许亚茹;李静;杨娜
【期刊名称】《中华老年心脑血管病杂志》 【年(卷),期】2011(013)002
【摘要】Objective To study the effect of blood lipids on plasma fibrinogen(Fib) concentration and conglomerate function, and the relation of blood lipids to Fib Bβ -854G/A,- 455G/A,-249C/T,-148C/T,448G/A and Bcl-1G/A gene polymorphisms. Methods 1386 retired employees from Kailuan Group were divided into 4 groups: non-high total cholesterol(TC) group (1138) ,high TC group(248) ,non-high triglyceride(TG) group(1131) ,high TG group(255). Plasma Fib concentration, fibrin monomer polymerization velocity (FMPV), maximum absorbance (Amax) and FMPV/A max were measured in all subjects. The gene polymorphisms at six sites were detected by PCR-RFLP. Results In high TC group,Fib concentration was higher in -854 mutant genotype crowd than in wild genotype crowd (P ＜ 0.05). In high TG group,Fib concentration,FMPV, A max and FMPV/A max were higher in -854 mutant genotype crowd than in wild genotype (P ＜ 0.05). The results of multiple stepwise regression analysis showed that with TC as dependent variable,sex,CRP,Bβ-854 genotype and smoking were selected (P ＜ 0.05) ;with TG as dependent variable, CRP, body mass
血脂与纤维蛋白原Bβ链基因多态性的关系及对其功能表达的影响
