Association of chronic obstructive pulmonary disease with coronary artery disease

Association of chronic obstructive pulmonary

disease with coronary artery disease

LIANG Bin-miao;XU Zhi-bo;YI Qun;OU Xue-mei;FENG Yu-lin

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2013(126)017

【摘要】Background The relationship between chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) remains largely unknown.This study aimed to explore the association of COPD with CAD,especially with multivessel disease (VD).Methods The data of 354 patients who underwent multi-detector computed tomography (MDCT) for suspected CAD were analyzed.Luminal narrowing was defined as at least one lesion 50％ or greater stenosis.The analysis of serum biochemistry profile and spirometrywere performed on all eligible patients,and the diagnosis of COPD was defined as the criteria of Global Initiative for Chronic Obstructive Lung Disease.Results Patients with CAD had a significantly higher complication of COPD than those without CAD (11.8％ vs.3.7％,P ＜0.001).Comparing with patients without COPD,those with COPD were more likely to have multi-VD,proportion of smoking and high C-reactive protein (CRP) (P ＜0.001).Multivariate Logistic regression analysis revealed that the multi-VD was significantly correlated with COPD (P=0.012) and CRP (P=0.015).Conclusions There was a high complication of COPD in