沙美特罗替卡松医治儿童中度哮喘的临床疗
效观看
【摘要】 目的:观看沙美特罗替卡松医治儿童中度哮喘的临床疗效。方式:82例中度哮喘患儿随机分为观看组和对照组,别离应用沙美特罗替卡松和布地奈德气雾剂医治1年,观看两组患儿哮喘急性发作次数及医治前后肺功能(FEV1和PEF估量值%)的转变。结果:观看组哮喘急性发作次数明显少于对照组;两组都可提高FEV一、PEF估量值%,改善肺功能,但医治组明显优于对照组。结论:沙美特罗替卡松医治儿童哮喘的临床疗效较好,能够作为儿童哮喘的首选医治。
【关键词】 沙美特罗替卡松;哮喘;儿童;布地奈德
[Abstract] Objective: To explore the efficacy of seretide in treating childhood patients with moderate asthma. Methods: Data of 82 asthmatic cases were gathered and randomly divided into two groups. The experimental group was treated with seretide and the control group with budesonide (BUD). The times of acute onset of asthma and Pulmonary Function (FEV1 and PEF) were analyzed statistically. Results: The times of acute onset of asthma was reduced in the experimental group than in the control group. The levels of FEV1 and PEF were increased in both groups. The improvement of Pulmonary Function was found better in the
experimental group than in the control group. Conclusions: Therapy with seretide produces better results than other drugs and it was the first choice of therapy for childhood asthma.
[Key words] Seretide; Asthma; Child; Budesonide
哮喘是一种严峻危害儿童健康成长的疾病。近30年来哮喘患病率及病死率均有所上升。目前全世界哮喘防治创议(Global Initiative for Asthma,GINA)推荐利用吸入糖皮质激素,使药物达到气道粘膜的靶细胞,可减少口服和静脉注射较大剂量激素引发全身不良反映。沙美特罗替卡松(Seretide)是用于医治儿童哮喘的最新一代吸入型药物。咱们应用沙美特罗替卡松医治42例儿童中度哮喘,现报导如下。
1 资料与方式
一样资料
选自2004年1月~2006年1月来我院儿科哮喘门诊就医符合儿童哮喘病防治常规的诊断及分度标准[1]的中度哮喘患儿82例,男50例,女32例,年龄5~14岁。随机分成观看组42例,对照组40例,两组患儿年龄、性别、病程比较不同无统计学意义(P>),具有可比性,见表1。
方式
两组患儿均于哮喘急性发作操纵后开始医治。观看组应用沙美特罗替卡松(葛兰素史克公司,每吸含沙美特罗50 μg,丙酸氟替卡松100 μg)2次/d,每次1吸,3个月后改成3次/2 d,每次1吸,6个月后改成1次/d,每次1吸,维持至1年。对照组应用布地奈德气雾剂(阿斯利康无锡制药,每揿含布地奈德200 μg)2次/d,每次1揿,3个月后改成3次/2 d,每次1揿,6个月后改成1次/d,每次1揿,维持至1年。小于7岁患儿均用储雾罐辅助吸入。两组总疗程1年,观看医治进程中急性发作次数、医治前后肺功能(FEV1和PEF估量值%)的转变和不良反映。表 1 两组一样资料比较 2 结果
两组患儿哮喘急性发作次数比较
结果见表2。经χ2查验,观看组与对照组比较不同有统计学意义(P<),对照组哮喘急性发作次数明显大于观看组。
表2 两组患儿疗程中哮喘急性发作次数比较(例)
组别例数发作0次1次2次3次对照组4020983观看组4235421
沙美特罗替卡松医治儿童中度哮喘的临床疗效观看
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