外泌体微小RNA与子痫前期发病机制的研究进展
赵雪娅;杨星宇;程蔚蔚
【期刊名称】《中华围产医学杂志》 【年(卷),期】2018(021)009
【摘要】Preeclampsia is an idiopathic gestational disease with unknown etiology or pathogenesis. Exosomes are membranous nanovesicles secreted by various cells, carrying contents such as proteins, mRNA, microRNA and lipids and being involved in regulations between cells by transporting the above contents through target cells. The expression of exosome-derived proteins and microRNAs in preeclampsia patients experiences changes, resulting in maternal inadequate trophoblast invasion, depressed endothelial cell function and angiogenesis. Research on placenta-derived exosomal microRNAs in preeclampsia patients may help to elucidate the pathogenesis of preeclampsia.%子痫前期是妊娠期特有的并发症,其病因和发病机制尚未完全阐明.外泌体是由多种细胞分泌的膜性纳米囊泡,携带蛋白、mRNA、微小RNA和脂质等内容物,通过靶细胞传递内含物,介导细胞与细胞之间的调控.子痫前期患者体内外泌体的蛋白和微小RNA的表达水平发生了变化,使母体滋养细胞侵袭能力不足、内皮细胞的功能和血管生成能力降低.对子痫前期患者胎盘组织来源的外泌体微小RNA进行研究,有助于阐明子痫前期的发病机制. 【总页数】4页(622-625)
【关键词】先兆子痫;外泌体;微RNAs
外泌体微小RNA与子痫前期发病机制的研究进展
