Common SNPs of APM1 Gene Are Not Associated With Hypertension or Obesity in Chinese Population

Common SNPs of APM1 Gene Are Not Associated

With Hypertension or Obesity in Chinese

Population

WEI-LI YAN;SHU-FENG CHEN;JIAN-FENG HUANG;YAN SHEN;Bo-QIN QIANG;DONG-HAI LIU;DONG-FENG GU

【期刊名称】《生物医学与环境科学（英文版）》 【年(卷),期】2006(019)003

【摘要】Objective To investigate whether the common variants 45T/G and 276G/T in APM1 gene were associated with hypertension combined with obesity (HO) and related clinical features in Chinese Han population. Methods A case-control study design was applied. Common polymorphisms of 45T/G and 276G/T were getotyped by PCR product sequencing in 484cases with HO and 502 controls with normal blood presure and BMI ＜ 25. Results The genotype and allele frequencies of 45T/G, 276G/T, and haplotype defined by the two variants in cases did not differ from those in controls. The means of blood pressure, BMI and waist-hip ratio did not differ among genotypes of the two polymorphisms and haplotypes. Among lipid profiles, only serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in T allele carriers than that in non-T carriers after adjusting possible confounding factors (1.21 vs 1.32 mmol/L, P=0.0001). Conclusion Polymorphisms of 45T/G and 276G/T in APM1 gene are not associated