多西紫杉醇联合卡培他滨治疗晚期乳腺癌的疗效观察

多西紫杉醇联合卡培他滨治疗晚期乳腺癌的疗效观察

田新庆;王文珍;王小娜

【期刊名称】《现代肿瘤医学》 【年(卷),期】2012(020)012

【摘要】Objective:To observe the curative effect and toxicity of semimonthly docetaxel plus capecitabine in ad-venced breast cancer patients who were drug resistance in using anthracene nucleus drugs. Methods: All 36 patients with advanced breast cancer who had received anthracycline chemotherapy before (5 patients had been treated with paclitaxel) were observed. These patients received docetaxel combined with capectabine for 2 -4 cycles. Three weeks as one cycle. Efficacy was evaluated after 2 cycles. Results: Of these 36 patients, 5 patients got complete remission, 19 patients partial remission,9 pationts stable disease , and 3 patients progression. The overall response rate was 66.7%. The main toxicities were alopecia, neutropenia, and other side effects were mild. There was no any death during treatment. Conclusion: Combintion chemotherapy of semimonthly docetaxel and capecitabine has a good anti - tumor effect and tolerable toxicity on advanced breast cancer patients who were drug resistant in using anthracene nucleus drugs.%目的:观察多西紫杉醇联合卡培他滨方案对蒽环类耐药的晚期乳腺癌患者的临床疗效及毒副作用.方法:36例既往接受过蒽环类(其中5例接受过紫杉醇)等药物化疗的晚期乳腺癌患者,均有临床观察指标,采用多西紫杉醇联合卡培他滨