非小细胞肺癌肿瘤相关巨噬细胞表型检测及临床意义
马薇;罗殿中;陈源;党裔武
【期刊名称】《山东医药》 【年(卷),期】2011(051)008
【摘要】Objective To study the relationship between the tumor-associated maerophage phenotypes and the clinical prognosis of non-small cell lung cancer (NSCLC) patients. Methods Immunohistochemical staining for CD68, TNF-α and TGF-β1 were performed on paraffin embedded tissues from 47 NSCLC cases. The relationship between immunohistochemical staining results and the relative clinicopathologic data and prognosis of NSCLC patients were analyzed. Results CD68+TNF-α + macrophage ( M1 ) was significantly lower in NSCLC than that in tumor surrounding lung tissues ( P ＜ 0. 05 ) and CD68+TNF-β1+ macrophage (M2) was significantly higher in NSCLC than that in tumor surrounding lung tissues (P ＜ 0. 05 ). M1 and M2 macrophages expression were correlated with clinical stage (P ＜ 0. 05 ). Kaplan-Meier analysis showed that up-regulating of CD68+ TNF-α+ macrophage expression was associated with higher survival rate of patients after operation, up-regulating of CD68+ TNF-β1+ macrophage expression was associated with lower survival rate of patients after operation. Conclusion M1 macrophage decreasing and M2 macrophage increasing were correlated with lower survival rate of
非小细胞肺癌肿瘤相关巨噬细胞表型检测及临床意义
