多西紫杉醇联合顺铂同期放疗治疗局部晚期食管癌的疗效
及其毒副反应
张汀荣;赵韬;徐昕;顾小伟;潘宇凯
【期刊名称】《中华肿瘤杂志》 【年(卷),期】2010(032)010
【摘要】Objective To investigate the therapeutical effect and side-effect of docetaxel combined with cisplatin (DDP) on the treatment of local advanced esophageal cancer with concomitant radiation therapy. Methods Ninety patients with LOCAL advanced esophageal squamous cell carcinoma were divided into two groups: ( DDP +5-Fu) group and (docetaxel + DDP) group. Chemotherapy was carried out every 4 weeks for a total of 4 courses. The radiation dose was 50.4 Gy/28 FX. Results The median survival time of patients in the (DDP +5-Fu) group was 16 months and that in (docetaxel + DDP) group was 21 months (P =0.0278). The 3-year survival rate in the (docetaxel + DDP) group was obviously higher than that inthe (DDP+5-Fu) group (23.9% vs. 12.1%). The ORR in (docetaxel +DDP) group (84.5%) was significantly higher than that in the (DDP +5-Fu) group (71.1%) (P =0.025 ). No significant differenceswere observed in the incidence of side-effects in the two groups. Conclusions The conventional dose chemotherapy of docetaxel + DDP with concomitant radiation therapy showed a better partial remission rate and long-term survival rate for the treatment of local
多西紫杉醇联合顺铂同期放疗治疗局部晚期食管癌的疗效及其毒副反应
