Blockage of IGF-1R signaling sensitizes urinary bladder cancer cells to mitomycin-mediated

Blockage of IGF-1R signaling sensitizes urinary bladder cancer cells to mitomycin-mediated

cytotoxicity

佚名

【期刊名称】《细胞研究（英文版）》 【年(卷),期】2001(011)002

【摘要】A major problem which is poorly understood in the management of bladder cancer is low sensitivity to chemotherapy and high recurrence after transurethral resection.Insulin-like growth factor 1 receptor(IGF-1R)signaling

plays

a

very

important

role

in

progression,invasion and metastasis of bladder cancer cells.In this study,we investigated whether IGF-1R was involved in the growth stimulating activity and drug resistance of bladder cancer cells.The results showed: The mRNAs of IGF-1,IGF-2 and IGF-1R were strongly expressed in serum-free cultured T24 cell line,whereas normal urothelial cells did not express these factors/receptors or only in trace levels; T24 cell responded far better to growth stimulation by IGF-1 than did normal

urothelial

cells;

blockage

of

IGF1R

by

antisense

oligodeoxynucleotide(ODN)significantly inhibited the growth of T24 cell and

enhanced

sensitivity

and

apoptosis

of

T24

cells

to

mitomycin(MMC).These results suggested that blockage of IGF-IR signaling might potentially contribute to the treatment of bladder

cancer cells which are insensitive to chemotherapy. 【总页数】9页(107-115) 【关键词】 【作者】佚名

【作者单位】Department of Biological Regulation, Weizmann Institute of Science,;Shanghai Institute of Materia Medica, Chinese Academy of Sciences,;Shanghai Institute of Materia Medica, Chinese Academy of Sciences,

【正文语种】中文 【中图分类】Q2 【文献来源】

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