Efficacy of Long-term Selenium Supplementation in the Treatment of Chronic Keshan Disease

Efficacy of Long-term Selenium Supplementation in the Treatment of Chronic Keshan Disease with

Congestive Heart Failure

Yan-he ZHU[1];Xin-feng WANG[2];Guang YANG[3];Jin WEI[4];Wu-hong TAN[1];Li-xin WANG[1];Xiong GUO[1];Mikko J.Lammi[1,5];Jie-hua XU[6];;

【期刊名称】《当代医学科学(英文)》 【年(卷),期】2019(039)002

【摘要】Few effective treatments for chronic Keshan disease have been available till now.The efficacy of long-term selenium supplementation in the treatment of chronic Keshan disease with congestive heart failure is inconclusive.This study aimed to determine whether selenium supplementation is associated with a decreased risk of cardiac death in chronic Keshan disease with congestive heart failure by ten years of follow-up.A retrospective long-term follow-up analysis was performed on a monitored cohort consisting of 302 chronic Keshan disease patients with a mean age of 40.8±11.4 years.Of the 302 chronic Keshan disease patients,170(56.3%)were given selenium supplementation until the end point of follow-up.Cox proportional hazards regression models were used to identify the independent predictors of cardiac events.Our results showed that during the follow-up,there were 101 deaths of patients with chronic Keshan disease in the selenium supplementation group(101/170,59.4%)and

98

in

non-selenium

supplementation