Product Data?SheetGlucosamineCat. No.:CAS No.:分?式:分?量:作?靶点:HY-B11253416-24-8C?H??NO?179.17Endogenous Metabolite; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Autophagy作?通路:储存?式:Metabolic Enzyme/Protease; Immunology/Inflammation; NF-κB; AutophagyPowderIn solvent-20°C4°C-80°C-20°C3 years2 years6 months1 monthInhibitors?Agonists?Screening Libraries溶解性数据体外实验H2O : 100 mg/mL (558.13 mM; Need ultrasonic)DMSO : 3.33 mg/mL (18.59 mM; Need ultrasonic)Mass1 mg5 mg10 mgSolventConcentration制备储备液1 mM5 mM10 mM5.5813 mL1.1163 mL0.5581 mL27.9065 mL5.5813 mL2.7906 mL55.8129 mL11.1626 mL5.5813 mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；?旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存?式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个?内使?，-20°C 储存时，请在 1 个?内使?。BIOLOGICAL ACTIVITY?物活性Glucosamine (D-Glucosamine) 是?种氨基糖, 是糖基化蛋?和脂质?化合成的突出前体, ?作膳?补充剂。Glucosamine 也是软?基质和滑液中糖胺聚糖的天然成分，当外?时，对?关节炎软?和软?细胞具有药理作?。IC?? & Target体外研究Human Endogenous MetaboliteGlucosamine (D-Glucosamine) exhibits dose-dependent DPPH antioxidant activity[2]. Glucosamine treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins[3]. Glucosamine significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells[4]. Page 1 of 2
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????Microbiome. 2024 Mar 20;7(1):43.
????Laurea Magistrale in Biomedical Engineering, Politecnico di Milano. 2024 Jun.See more customer validations on www.MedChemExpress.cnREFERENCES
[1].?Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S12-7.
[2].?Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9.
[3].?Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706.
[4].?Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84.
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