Decreased proliferation ability and differentiation potential of mesenchymal stem cells of

Decreased proliferation ability and differentiation

potential of mesenchymal stem cells of

osteoporosis rat

Qiang Wang;Bing Zhao;Chao Li;Jie-Sheng Rong;Shu-Qing Tao;Tian-Zun Tao

【期刊名称】《亚太热带医药杂志（英文版）》 【年(卷),期】2014(000)005

【摘要】Objective:To explore decreased proliferation ability and differentiation potential of mesenchymal stem cells(MSCs) of osteoporosis rat.Methods:MSCs were obtained from osteoporosis rat, and proliferation potency and impaired osteogenic differentiation potential were determined. Results:The result showed a significant downregulation ofMSCs pluripotency related gene(Oct 4) and osteogenic

genes(BSP,OCN)

expression

inOVXMSCs

compared

withShamMSCs(P<0.05). Conclusions:These data suggest thatMSCs are aging in osteoporosis body, and autologous OVXMSCs transplantation is not appropriate to treat osteoporosis if necessary.There will be a possibility in establishing a new clinical application ofMSCs autologous transplantation to treat osteoporosis, ifOVXMSCs have stronger proliferation and differentiation. 【总页数】6页(358-363) 【关键词】

【作者】Qiang Wang;Bing Zhao;Chao Li;Jie-Sheng Rong;Shu-Qing

Tao;Tian-Zun Tao

【作者单位】2nd Department of 0rthopaedic Surgery, No.2 Affiliated Hospital of Harbin Medical University, Heilongjiang Province 150086, China;2nd Department of 0rthopaedic Surgery, No.2 Affiliated Hospital of Harbin Medical University, Heilongjiang Province 150086, China;2nd Department of 0rthopaedic Surgery, No.2 Affiliated Hospital of Harbin Medical

University,

Heilongjiang

Province

150086,

China;2nd

Department of 0rthopaedic Surgery, No.2 Affiliated Hospital of Harbin Medical

University,

Heilongjiang

Province

150086,

China;2nd

Department of 0rthopaedic Surgery, No.2 Affiliated Hospital of Harbin Medical

University,

Heilongjiang

Province

150086,

China;2nd

Department of 0rthopaedic Surgery, No.2 Affiliated Hospital of Harbin Medical University, Heilongjiang Province 150086, China 【正文语种】英文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_asia-pacific-tropical-medicine-journal-english_thesis/0201254094481.html 【相关文献】

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