肿瘤标志物在肝细胞癌合并门静脉癌栓诊断中的意义
刘洋;王宪强;于牧川;姜凯;张文智
【期刊名称】《中国现代普通外科进展》 【年(卷),期】2012(015)012
【摘要】Objective: To analysis tumor markers in diagnosis hepatocellular carcinoma with portal vein tumor thrombus. Method: Retrospective analysis 475 HCC patients with PVTT diag-nosed by imaging from January 1993 to January 2011 in our hospital, whilst randomly selected 977 HCC cases who underwent hepatectomy. The alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), cancer antigen 125 (Ca125) were taken into account as experimental factors. Results; There was no significant difference in gender and age. ROC analysis showed that area under curve (AUC) of AFP, CA125 is 0.814 and 0.783,respectively, cut-off values were AFP=32.91 ng/mL and CA125=113.65 U/mL. When paralleled, sensitivity and specificity is 0.909 and 0.410. When seried, sensitivity and specificity 0.520 and 0.970. On condition the HCC meet AFP ≥20 000 ng/mL, its diagnostic sensitivity was 0.24, specificity 0.96, accuracy 0.73, positive rate of screening 0.76. Conclusion: The tumor markers commonly used in the detection of hepatocellular carcinoma with portal vein tumor thrombus had no satisfactory sensitivity and specificity. HCC patients who meet AFP＞ 32.91 ng/mL and CA125＞113.65 U/mL or the AFP ≥20 000 ng/mL, its specificity of 0.97 and 0.96,
肿瘤标志物在肝细胞癌合并门静脉癌栓诊断中的意义
