肺结核耐药和耐多药的危险因素分析

肺结核耐药和耐多药的危险因素分析

李华

【期刊名称】《中国实用医刊》 【年(卷),期】2018(045)012

【摘要】目的 分析肺结核耐药和耐多药的危险因素.方法 选取医院检验科结核实验室1 550 株结核分枝杆菌复合群菌株行药敏试验,并采用Logistics多元回归分析统计耐多药产生的危险因素.结果 1 550 株结核分枝杆菌复合群菌株中,有939株(60.58%)对6种抗结核药物均敏感,611株(39.42%)为耐药菌,其中耐多药菌388株(25.03%)、广泛耐药62株(4.00%),从低到高耐药率分别为:卡那霉素39 株(2.52%)、氧氟沙星112 株(7.23%)、乙胺丁醇 150 株(9.68%)、链霉素 305 株(19.68%)、利福平 389 株(25.10%)和异烟肼 450 株(29.03%).根据Logistics多元回归分析结果显示,18～40岁、41～60岁以及具有结核治疗史是影响肺结核耐药和耐多药的危险因素(P＜0.05).结论 肺结核患者具有较高的耐药性,其中18～40岁、41～60岁以及具有结核治疗史使其耐药性和耐多药的可能性升高.%Objective To analyze the risk factors of drug resistance and multi-drug resistance in pulmonary tuberculosis. Methods A total of 1 550 Mycobacterium tuberculosis complex strains were tested for drug susceptibility,and Logistics multiple regression analysis was used to analyze the risk fac-tors of multi-drug resistance. Results In 1 550 strains of Mycobacterium tuberculosis strains,939 strains (60.58%)were sensitive to 6 kinds of anti-tuberculosis drugs,611 strains (39.42%)were drug-resistant bacteria,including 388 strains (25.03%)of multi-drug

resistant bacteria,62 strains of extensively drug-resistant (4.00%),from low to high resistance rates were:kanamycin 39 strains (2.52%),ofloxacin 112 strains (7.23%)ethambutol 150 strains (9.68%),streptomycin 305 strains (19.68%),rifampicin 389 strains (25.10%)and isoniazid 450 strains (29.03%). According to Lo-gistics multiple regression analysis,it was showed that 18-40 years old,41-60 years old and the histo-ry of tuberculosis treatment were the risk factors of tuberculosis drug resistance and multi-drug resistance (P＜0.05 ). Conclusions The pulmonary tuberculosis patients have high drug resistance,including 18-40,41-60 years old and tuberculosis treatment history will increased multidrug resistance and the probability of multi-drug resistance. 【总页数】4页(69-72)

【关键词】肺结核;耐药;耐多药;危险因素;分枝杆菌 【作者】李华

【作者单位】041000 山西省临汾市第三人民医院结核科 【正文语种】中文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-practical-medicine_thesis/0201255067847.html 【相关文献】

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