胃混合性腺神经内分泌癌4例临床病理分析
雷瑞雪;苗兰芳;郭梅
【期刊名称】《中国实用医刊》 【年(卷),期】2017(044)001
【摘要】Objective To investigate the clinical and pathological features of gastric mixed ade-noneuroendocrine carcinoma(MANEC). Methods From January 2013 to January 2016,2 628 cases were diagnosed with gastric adenocarcinoma,from which to choose four cases of mixed adenoneuroendo-crine carcinoma by immunohistochemistry,and all slides
in
the
files
were /
AE3
reviewed. and clinical
The
interpretation
detected
of by
Syn,CgA,CD56,NSE,AE1 immunohistochemistry.
Ki-67 were
The symptoms, pathological,
characteristics, treatment and prognosis were retrospectively analyzed. Results
The
main
clinical
manifestations
were
non-specific
symptoms,such as abdominal discomfort. MANEC was composited by adenocarcinoma and neuroendocrine neoplasm,each one comprising at least 30% of the tumor. AE1 / AE3 was expressed in adenocarcinoma components. AE1 / AE3,Syn,CD56, NSE and CgA were expressed in neuroendocrine components in different degrees. Ki-67 index was ﹥ 70% in all cases. Conclusions The diagnosis of MANEC is rested on histology and immunohis-tochemistry and the prognosis of MANEC is worse than that of the common adenocarcinoma.%目的：探讨胃混合性腺神经内分泌
胃混合性腺神经内分泌癌4例临床病理分析
