米氮平与帕罗西汀治疗抑郁症对照研究
魏冬;席永稳
【期刊名称】《临床心身疾病杂志》 【年(卷),期】2015(000)003
【摘要】Objective To explore the efficacy and safety of mirtazapine and paroxetine in the treatment of depression .Methods Seventy‐eight depression patients were randomly assigned to two groups taking o‐rally mirtazapine or paroxetine for 8 weeks .Efficacies were assessed with the Hamilton Depression Scale (HAMD) before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results After treatment the HAMD scores of both groups lowered more significantly compared with pretreatment (P< 0 .01) ,so did that in mirtazapine than in paroxetine group at the end of the 1st week (P<0 .01) ,at the end of the 8th week obvious and total effective rate were respectively 74 .4% and 92 .3% in mirtazapine and 71 .8% and 94 .9% in paroxetine group ,which showed no significant group differences (χ2 =0 .07 ,0 .21;P>0 .05) .Adverse reactions of both groups were mild and their incidences had no significant group differences (P>0 .05) .Conclusion Both mirtazapine and paroxetine have an evi‐dent effect in depression ,their total efficacies are equivalent ,but the former takes effect more rapidly and is beneficial to the increase of early treatment confidence and the improvement of patients ’ quality of
米氮平与帕罗西汀治疗抑郁症对照研究
