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戊四氮诱导发育鼠癫痫持续状态后海马内
神经发生与突触重塑的研究
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2016年10月
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**硕士学位论文 缩 略 词 表 Abbreviation 缩略词 BrdU BDNF COD CNS DAB DG GCL GFAP i.p. IGF-I KA LTP MK-801
英文全称 5-bromo-2’-deoxyuridine Brain-derived neurotrophic factor Corrected opitical density 缩略词表说明： Central nervous system 由“缩略词表”开始，以后每页均需按此要求设置页眉页脚： 中文全称 5-溴脱氧尿核苷 脑源性神经营养因子 校正吸光度 中枢神经系统 Diaminobenzidine 3,3- 2.2 页脚：1.75 一、页面设置：上：3 下：2.5 左：3 右：3 二氨基联苯胺装订线：0 页眉：Dentate gyrus 页码居中 齿状回 颗粒细胞层 胶质原纤维酸性蛋白 腹腔内注射 Granule cell layer Glial fibrillary acidic protein Introperitioneal 字间距：1个字符空 二、“缩略词表”：4号宋体加粗 居中 行距：2倍行距 段前段后：各1行 三、“Abbreviation”：4号Times New Roman 居中 行距：2倍行距 段前段后：各1行 Insulin-like growth factor-I 胰岛素样生长因子Kainic acid
Long-term potentiation 5-methyl-10,11-dihydro -5H-dibenzocyclohepten-
红藻氨酸（海人酸） 长时程增强 5-甲基二氢二苯并环 庚烯亚胺马来酸
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**硕士学位论文
戊四氮诱导发育鼠癫痫持续状态后海马内
神经发生和突触重塑的研究
中 文 摘 要
目的 目前，对癫痫反复发作的病因的说法很多，但齿状回颗粒细胞的神经发生增加，颗粒细胞的苔藓纤维异常发芽及伴随的突触重塑已被认为是其细胞机制之一。故近年有关神经发生和突触重塑的研究正成为脑科学中令人瞩目的热点，但是这些现象对临床上常见的儿童癫痫反复发作的病因是否有作用，目前还少有中文摘要说明： 报道。 一、标题：小2号黑体 居中 行距：单倍行距 二、“中文摘要”：4号宋体 加粗 居中 字间距：1个字符空 行距：多方法 腹腔注射戊四氮制作发育期SD大鼠（7天、14天、21天和28天四个日龄组）癫痫持续状态(SE)发作模型，再将各日龄组随机分为NS组、SE组和MK-801组，选择处理后第7天、14天和28天三个时间点进行观察。 结果 BrdU免疫反应产物：SE发作后第7天和14天，SE组中各日龄组幼鼠齿状回BrdU阳性细胞数明显高于各自的NS组（P＜0.01），而MK-801组较SE组明显减少（P＜0.05），但在第28天三组之间无明显差异（P＞0.05）；发作后第7天，三组中大部分BrdU阳性细胞分布于颗粒下层。
结论 1.癫痫持续状态发作可使不同日龄的发育鼠脑内齿状回神经元发生数量的增加、位置的迁移和异位以及突触的重塑。2.NMDA受体在癫痫后的神经元发生和突触重塑中起着促进作用。
关键词 发育鼠,癫痫持续状态,突触素,海马,BrdU,MK-801
倍行距4
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盲审论文格式-2016课件
