3q27-3q29相关的p63蛋白表达在弥漫性大B细胞淋巴
瘤中的意义
陈振文;王晋芬;王国平;张宏伟;刘冬梅;徐义荣;张朝霞;田林
【期刊名称】《白血病·淋巴瘤》 【年(卷),期】2010(019)003
【摘要】目的 探讨3q27-3q29相关的p63蛋白表达在弥漫性大B细胞淋巴瘤(DLBCL)中的意义.方法 应用免疫组织化学EnVision二步法检测102例DLBCL与15例反应性淋巴组织增生(RHL)中p53蛋白和3q27-3q29相关的p63蛋白的表达并进行随访.结果 p53、p63蛋白在DLBCL中的阳性率分别为62%和56%,在RHL中的阳性率分别为0和13%,p53、p63蛋白在DLBCL与RHL中比较差异均有统计学意义(P<0.05);p53、p63蛋白的表达在Ⅰ+Ⅱ期中的阳性率分别为48.3%和41.4%,在Ⅲ+Ⅳ期中的阳性率分别为79.5%和75%,差异有统计学意义(P<0.05);p53、p63蛋白的表达在生发中心B细胞型(GCB型)中的阳性率分别为28%和28%,在非GCB型(non-GCB型)中的阳性率分别为72.7%和64.9%,差异均有统计学意义(P<0.05).p53、063蛋白表达与患者性别、年龄、有无B症状和发病部位等无相关性(P>0.05).p53蛋白表达与p63蛋白表达呈正相关性(r=0.629,P<0.05).p53、063蛋白表达阴性组的5年总体生存率高于阳性组(38%:6%,51%:4%),差异有统计学意义(P<0.05).结论 p63可能作为癌基因与p53共同参与了DLBCL的发生和发展,两者在肿瘤的发生中可能起着协同作用;联合检测p63蛋白和p53蛋白在DLBCL中的表达,可能成为判断DLBCL预后指标之一.%Objective To investigate the expressions and clinicopathological significance of 3q27-3q29-related p63 protein in
diffuse large B-cell lymphoma (DLBCL). Methods An
immunohistochemical Envision~(TM) method was used to detect the expressions of p53 and 3q27-3q29-related p63 protein in 102 cases of DLBCL and 15 cases of reactive hyperplasia of lymph node (RHL). Results The tumor cell expressions of p53(62 %) and p63(56 %) in DLBCL were significantly higher than that in RHL (0 and 13 % P < 0.05). The expressions of p53 and p63 were significantly different (1) between stage Ⅰ + Ⅱ (the positive rate 48.3 % and 41.4 %, respectively) and stage Ⅲ+Ⅳ(the positive rate 79.5 % and 75 %, respectively; P <0.05), (2) between GCB type (the positive rate 28 % and 28 %, respectively) and non-GCB type(the positive rate 72.7 % and 64.9 %, respectively; P <0.05). The expressions of p53 and p63 had no relationship to gender, age, B symptoms and locations. The expression of p53 was positively correlated with that of p63 in DLBCL (P <0.05, Cp=0.629). p53 and p63 protein expression in negative group the 5-year overall survival rate is higher than that in positive group (38 % and 6 %, 51% and 4 %, respectively), the difference was statistically significant (P <0.05). Conclusion It was likely that p63, as the oncogene, participated in the occurrence and development of DLBCL together with p53. Also, p63 and p53 might play a synergistic role in the occurrence DLBCL. Combined detection of 3q27-3q29-related 1963 protein and p53 protein in DLBCL, might be one of the indicators to the prognosis of DLBCL.
【总页数】5页(161-165)
【关键词】淋巴瘤,大细胞,弥漫型;基因;p53;p63;3q27-3q29;免疫组织化学3.山西省肿瘤医院血液科
【作者】陈振文;王晋芬;王国平;张宏伟;刘冬梅;徐义荣;张朝霞;田林
【作者单位】032200,山西医科大学汾阳学院病理学教研室;山西省肿瘤医院病理科;华中科技大学同济医学院病理学系;山西省肿瘤医院血液科;032200,山西医科大学汾阳学院病理学教研室;032200,山西医科大学汾阳学院病理学教研室;032200,山西医科大学汾阳学院病理学教研室;山西医科大学附属汾阳医院病理科
【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_journal-leukemia-lymphoma_thesis/0201236434984.html 【相关文献】
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3q27-3q29相关的p63蛋白表达在弥漫性大B细胞淋巴瘤中的意义
