大豆异黄酮对非酒精性脂肪肝大鼠肝脏脂代谢的影响
冷亮;蒋卓勤;纪桂元
【期刊名称】《中华预防医学杂志》 【年(卷),期】2011(045)004
【摘要】Objective To study the effects of soybean isoflavone on liver lipid,serum lipid,antioxidant index and hepatic lipid metabolism associated factors in nonalcoholic fatty liver rats.Methods Thirty-six male rats(SD)were randomly divided into four groups by weight: normal control group,nonalcoholic fatty liver disease(NAFLD) model control group,low-dose isoflavone treatment group (10 mg/kg)and high-dose isoflavone group(20 mg/kg),9 rats in each group.Normal control rats were fed with D12450B(10% fat energy),model control and isoflavone intervention rats were fed with D12492(60út energy).Twelve weeks later,liver lipid,serum lipid and antioxidant index were observed.Liver sterol regulatory element binding protein-1 c(SREBP-1 c),fatty acid synthase(FAS)and
Peroxisome
proliferators
activated
receptor
alpha(PPAR alpha)were detected by western blotting.Results Liver triglyceride(TG)in
normal
control
group,NAFLD
model
control
group,low-dose isoflavone group and high-dose isoflavone group were(8.11
±
4.13),(57.06
±
16.95),(31.26
±
10.48),(31.38
±
13.25)mmol/mg protein,respectively(F = 22.569,P ＜0.01); liver free fatty acid(FFA)were(0.030 ± 0.007),(0.042 ± 0.009),(0.038 ± 0.009),(0.032 ±
大豆异黄酮对非酒精性脂肪肝大鼠肝脏脂代谢的影响
