免疫法粪便隐血试验检测大肠癌准确度的Meta分析
姜岩松;刘国祥;黄慧瑶;黄卫东;张歆;付文琦;代敏;石菊芳
【期刊名称】《中华预防医学杂志》 【年(卷),期】2015(000)005
【摘要】目的：对免疫法粪便隐血试验（iFOBT）检测大肠癌的准确度进行Meta分析。方法基于PubMed和Embase检索获得与大肠癌iFOBT筛查技术有关的文献共1197篇,检索时间截止至2014年6月。最终筛选出17篇文献。采用双变量混合效应模型进行效应值合并和异质性检验，对大肠癌筛查的灵敏度及特异度进行推断。进一步进行亚组分析，把所有筛查者中均行肠镜检查定义为肠镜组，以对筛查阳性者进行肠镜检查，并对所有筛查者进行随访定义为随访组，对不同亚组的灵敏度和特异度进行分析。并以筛查结果判断方式区分定性组和定量组，对不同亚组的灵敏度和特异度进行分析。结果纳入的17篇文献共有调查人数161502名，年龄范围是48～63岁。通过数据合并分析得到iFOBT筛查技术对于大肠癌的总体灵敏度为0.85（95%CI：0.79～0.89），异质性检验Q=59.67，P<0.001；特异度为0.93（95%CI：0.92～0.94），异质性检验结果Q=1722.53，P<0.001。亚组分析发现，在肠镜组和随访组iFOBT的合并灵敏度分别为0.81（95%CI：0.73～0.87）和0.88（95%CI：0.81～0.92）；特异度分别为0.92（95%CI：0.89～0.93）和0.95（95%CI：0.94～0.96）。定性组和定量组的合并灵敏度分别为0.84（95%CI：0.76～0.90）和0.86（95%CI：0.78～0.92），特异度分别为0.94（95%CI：0.91～0.96）和0.93（95%CI：0.91～0.94）。结论 iFBOT检测大肠癌的灵敏度和特异度均较高。%Objective To assess the accuracy of immunological fecal
occult blood test (iFOBT) for detection of colorectal cancer (CRC). Methods A total of 1 197 studies published before June 2014 were selected from PubMed and Embase and 17 of which were finally included in this meta-analysis. A bivariate mixed-effects models was used for overall value merging and heterogeneity testing. In addition to the overall sensitivity and specificity, the analyses were also performed among certain subgroups, including a“colonoscopy group”(all were referred for colonoscopy diagnosis regardless screening results) and a\group\(only the screening positive were referred and all were then followed up), a qualitative group and a quantitative group (classified by the way of iFOBT result reading). Results A total of 161 502 subjects aged from 48 to 63 years were included in the analysis. IFOBT had
an
overall
integrated
sensitivity
of
0.85
(95%CI:0.79-
0.89)(heterogeneity test:Q=59.67,P<0.001)and an overall integrated specificity
of
0.93
(95%CI:0.92-0.94)(heterogeneity
test:Q=1
722.53,P<0.001)for detection of CRC. In the subgroup analysis, it was found that in the\sensitivity were 0.81 (95%CI: 0.73-0.87) and 0.88 (95%CI: 0.81-0.92), respectively; the specificity were 0.92 (95%CI: 0.89-0.93) and 0.95 (95%CI: 0.94-0.96), respectively. It was also found that in the qualitative group and the quantitative group, the sensitivity were 0.84 (95%CI:0.76-0.90) and 0.86 (95%CI:0.78-0.92), respectively;the specificity were 0.94
(95%CI: 0.91-0.96) and 0.93 (95%CI: 0.91-0.94), respectively. Conclusion IFOBT had high overall sensitivity and specificity for detecting colorectal cancer.
【总页数】7页(392-398)
【关键词】结直肠肿瘤;敏感性与特异性;免疫法粪便隐血试验;Meta分析 【作者】姜岩松;刘国祥;黄慧瑶;黄卫东;张歆;付文琦;代敏;石菊芳
【作者单位】150086哈尔滨医科大学卫生管理学院;150086哈尔滨医科大学卫生管理学院;中国医学科学院肿瘤医院全国肿瘤防治研究办公室城市癌症早诊早治项目办公室;150086哈尔滨医科大学卫生管理学院;150086哈尔滨医科大学卫生管理学院;150086哈尔滨医科大学卫生管理学院;中国医学科学院肿瘤医院全国肿瘤防治研究办公室城市癌症早诊早治项目办公室;中国医学科学院肿瘤医院全国肿瘤防治研究办公室城市癌症早诊早治项目办公室 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-preventive-medicine_thesis/0201215343070.html 【相关文献】
1.5-Fu与IFNα-2b联合治疗晚期大肠癌的肿瘤反应率和毒性:6个随机对照临床试验的Meta分析 [J], 邹鸿志; 郁宝铭; 黎才海; 舒味冰; 赵任
2.应用CLSI EP12-A2评价免疫-化学双联法检测粪便隐血试验准确度 [J], 郑惠心
免疫法粪便隐血试验检测大肠癌准确度的Meta分析
