微血管侵犯对单发小肝癌患者术后无进展生存期的影响
陈星;李强;荀晓冬;周洪渊
【期刊名称】《中华肝胆外科杂志》 【年(卷),期】2016(022)002
【摘要】Objective To study the influence of microvascular invasion (MVI) on progression-free survival (PFS) in patients with a solitary small hepatocellular carcinoma,and to analyze the risk factors of MVI.Methods 126 patients with a solitary small hepatocellular carcinoma who underwent liver resection at Tianjin Medical University Cancer Hospital from January 2010 to December 2012 were retrospectively studied.Their demographic age,gender,HBV
and
clinicopathological
infection,HCV
characteristics
including
infection,alcohol
size,tumor TBil
were
consumption,comorbidity,liver differentiation,MVI,satellite
cirrhosis,ascites,tumor
and
lesion,AFP,CA19-9,ALT
analyzed.Results The 1-,2-and 3-year PFS rates of patients with a solitary small hepatocellular carcinoma were 81.0％,60.3％ and 47.3％ after surgical resection,respectively.Univariate analysis revealed that MVI,comorbidity,non-well-differentiated tumor,tumor size ＞4 cm were risk factors of PFS.Multivariate analysis demonstrated that only MVI and comorbidity were independent factors of PFS.MVI occurred in 43.7％ of the patients.The median PFS of patients without MVI was 45 months,and the 1-,2-and 3-year PFS rates of these patients were
91.5％,67.6％ and 56.0％,respectively.The median PFS of patients with MVI was 30 months,and the 1-,2-and 3-year PFS rates were 67.3％,50.9％ and 35.4％,respectively.On univariate analysis,AFP ＞ 100 μg/L,non-well-differentiated tumor and satellite lesions were significantly associated with MVI.On multivariate analysis only non-well-differentiated tumor was independently associated with MVI.Conclusions MVI was an important factor affecting PFS in patients with a solitary small hepatocellular carcinoma.AFP ＞ 100 μg/L,non-well-differentiated tumor and satellite lesions were risk factors of MVI.%目的 探讨微血管侵犯(MVI)对单发小肝癌患者术后无进展生存期的影响及其危险因素.方法 回顾性分析2010年1月至2012年12月我院手术治疗的126例单发小肝癌患者的临床病理资料.分析年龄、性别、乙肝及(或)丙肝病毒感染、饮酒史、合并症、腹水、肝硬化、肿瘤大小、肿瘤分化、MVI、卫星结节、AFP、CA19-9、ALT、TBil对术后无进展生存期的影响及MVI与上述临床病理指标的相关性.结果 单发小肝癌患者手术切除后1、2、3年无进展生存率分别为81.0％、60.3％、47.3％.单因素分析显示,MVI、合并症、肿瘤非高分化、肿瘤＞4 cm是影响单发小肝癌患者手术切除后无进展生存期的危险因素.多因素分析显示,MVI和合并症是影响单发小肝癌患者术后无进展生存期的独立危险因素.MVI发生率为43.7％.其中无MVI患者中位无进展生存期为45个月,1、2、3年无进展生存率分别为91.5％、67.6％、56.0％;有MVI患者中位无进展生存期为30个月,1、2、3年无进展生存率分别为67.3％、50.9％、35.4％.单因素分析显示,AFP＞ 100 μg/L、肿瘤非高分化和卫星结节是MVI的危险因素.多因素分析显示肿瘤非高
分化是MVI的独立危险因素.结论 MVI是影响单发小肝癌患者手术切除后无进展生存期的重要因素,AFP＞ 100 μg/L、肿瘤非高分化和卫星结节是MVI的危险因素,尤其是肿瘤非高分化. 【总页数】5页(94-98)
【关键词】单发小肝癌;无进展生存期;微血管侵犯;危险因素 【作者】陈星;李强;荀晓冬;周洪渊
【作者单位】300060 天津医科大学肿瘤医院肝胆肿瘤科;300060 天津医科大学肿瘤医院肝胆肿瘤科;300060 天津医科大学肿瘤医院肝胆肿瘤科;300060 天津医科大学肿瘤医院肝胆肿瘤科 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-hepatobiliary-surgery_thesis/0201234580695.html 【相关文献】
1.结肠癌根治术后FOLFOX或XELOX化疗的Ⅱ、Ⅲ期老年患者无复发生存期和总生存期及其影响因素分析 [J], 张帆; 罗庆锋
2.清肝化瘀颗粒联合TACE术对原发性肝癌患者无进展生存期和生存质量的影响 [J], 李伟良
3.影响小肝癌术后无瘤生存期的相关因素及治疗对策 [J], 赵文和; 马志敏; 周杏仁
4.重组人血管内皮抑制素联合肝动脉介入治疗对中晚期肝癌无疾病进展生存期
的影响 [J], 郝明志; 林海澜; 陈起忠; 胡育斌
5.原发性肝癌患者介入术后生存期的影响因素分析 [J], 李伟良
以上内容为文献基本信息，获取文献全文请下载
微血管侵犯对单发小肝癌患者术后无进展生存期的影响
