血脂异常且无糖尿病和高血压患者与健康对照者心-踝血管
指数的比较研究
桑城;郝恒剑;许骥
【期刊名称】《中国医药》 【年(卷),期】2016(011)002
【摘要】目的 比较血脂异常且无糖尿病和高血压患者与健康对照者心-踝血管指数(CAVI)的差异,为临床干预提供参考.方法 选取2012年9月至2014年5月于首都医科大学宣武医院治疗的血脂异常且无糖尿病和高血压患者169例作为观察组.其中,高胆固醇血症患者(FH亚组)103例,混合型高脂血症患者(CH亚组)66例.选取同期入院体检的264名健康志愿者纳入对照组.收集并比较观察组与对照组性别、年龄、体重指数、吸烟情况、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油、载脂蛋白A、载脂蛋白B、收缩压、舒张压和CAVI.结果 观察组、FH亚组及CH亚组的总胆固醇、LDL-C、三酰甘油、载脂蛋白B、舒张压与对照组比较[6.1(4.3,10.4)、6.4(4.3,9.6)、6.0(4.7,10.4) mmol/L比4.9(3.2,6.5) mmol/L,4.2(2.5,6.4)、4.3(2.5,6.1)、4.1(2.6,6.4) mmol/L比2.7(1.4,2.8) mmol/L,1.4(0.5,7.1)、1.2(0.5,7.0)、1.6(0.5,7.1)mmol/L比0.8(0.3,2.4) mmol/L,1.1(0.6,1.8)、1.3(0.7,1.8)、1.1(0.6,1.7)g/L
比
0.8(0.8,1.9)
g/L,80(70,101)
、
80(71,94)
、
80(73,101)mmHg(1 mmHg=0.133 kPa)比87 (71,103) mmHg],差异均有统计学意义(均P＜0.05);观察组、CH亚组的HDL-C和CAVI与对照组比较[1.6(1.0,2.5)、1.8(1.5,2.5) mmol/L比1.4(1.0,2.2) mmol/L,7.9(5.6,10.1)、8.4(6.1,10.1)比7.2(5.4,10.3)],差异有统计学意义(P＜0.05);CH亚组载脂蛋白A
低于对照组[1.5(1.3,3.2)g/L比1.7(1.2,3.3)g/L],差异有统计学意义(P＜0.05);FH亚组与CH亚组患者HDL-C、LDL-C和三酰甘油比较[1.4(1.0,2.2) mmol/L比1.8(1.5,2.5) mmol/L,4.3(2.5,6.1) mmol/L比4.1(2.6,6.4) mmol/L,1.2(0.5,7.0) mmol/L比1.6(0.5,7.1) mmol/L],差异有统计学意义(P＜0.05).Pearson直线相关分析结果表明,观察组总胆固醇和三酰甘油水平与CAVI呈正相关(r=0.283,P=0.026;r =0.383,P＜0.001).结论 血脂异常且无糖尿病和高血压患者与健康对照者相比CAVI明显增加,患者总胆固醇和三酰甘油水平与CAVI呈正相关.%Objective To compare the cardio-ankle vascular index (CAVI) between health persons and dyslipidemia patients without diabetes and hypertension.Methods One hundred and sixty-nine dyslipidemia patients (observation group) without diabetes and hypertension from September 2012 to May 2014 were selected and were divided into hypercholesterolemia subgroup (FH subgroup,103 cases) and hyperlipidemia subgroup (CH subgroup,66 cases).In addition,264 healthy volunteers were enrolled (control group).The gender,age,body mass index (BMI),smoking status,total cholesterol (TC),high
density
lipoprotein-cholesterol
(HDL-C),low
density
lipoprotein-cholesterol (LDL-C),triglyceride (TG),apoli poprotein A(Apo A),Apo B,blood pressure and CAVI were compared among groups.Results The levels of TC,LDL-C,TG,Apo B and diastolic blood pressure in observation group,FH subgroup and CH subgroup were all significantly different with those in control group [6.1 (4.3,10.4),6.4
(4.3,9.6),6.0 (4.7,10.4) mmol/L vs 4.9 (3.2,6.5) mmol/L,4.2 (2.5,6.4),4.3 (2.5,6.1),4.1 (2.6,6.4) mmol/L vs 2.7 (1.4,2.8) mmol/L,1.4 (0.5,7.1),1.2 (0.5,7.0),1.6 (0.5,7.1) mmol/Lvs0.8 (0.3,2.4) mmol/L,1.1 (0.6,1.8),1.3 (0.7,1.8),1.1 (0.6,1.7) g/L vs0.8 (0.8,1.9) g/L,80 (70,101),80 (71,94),80 (73,101) mmHg vs87 (71,103) mmHg] (P＜0.05);the HDL-C and CAVI in observation group and CH subgroup were significantly different with those in control group [1.6 (1.0,2.5),1.8 (1.5,2.5) mmol/L vs 1.4 (1.0,2.2) mmol/L,7.9 (5.6,10.1),8.4 (6.1,10.1) vs7.2 (5.4,10.3)] (P＜0.05);the Apo A in CH subgroup was significantly lower than that in control group [1.5 (1.3,3.2) g/L vs 1.7 (1.2,3.3) g/L] (P ＜ 0.05);the levels of HDL-C,LDL-C and TG in FH subgroup and CH subgroup were significantly different [1.4 (1.0,2.2) mmol/L vs 1.8 (1.5,2.5) mmol/L,4.3 (2.5,6.1) mmol/L vs 4.1 (2.6,6.4) mmol/L,1.2 (0.5,7.0) mmol/Lvs 1.6 (0.5,7.1) mmol/L] (P＜0.05).Pearson linear correlation analysis showed that TC and TG were positively correlated with CAVI in observation group (r =0.283,P =0.026,r =0.383,P ＜ 0.001).Conclusions Compared with that in healthy person,the CAVI were significantly increased in dyslipidemia patients without diabetes and hypertension;there were positively correlations between CAVI and TC,TG. 【总页数】5页(176-180)
【关键词】血脂异常;糖尿病;高血压;心-踝血管指数 【作者】桑城;郝恒剑;许骥
血脂异常且无糖尿病和高血压患者与健康对照者心-踝血管指数的比较研究
