降钙素原和hs-CRP在新生儿败血症诊断中的价值
李思袖;刘小乖;于淑群;赵玉娟;马海欣
【期刊名称】《中国妇幼健康研究》 【年(卷),期】2012(023)003
【摘要】目的 探讨血清降钙素原、超敏C-反应蛋白(hs-CRP)在新生儿败血症诊断中的价值.方法 败血症组146例在入院时及恢复期采血,用免疫色谱法和免疫浊法比分别测定降钙素原和hs-CRP,并在入院接受抗生素治疗前作血培养;非感染组113例一次性采血测定降钙素原和hs-CRP,并对两组进行比较分析.结果 败血症组降钙素原水平(15.19±12.87ng/mL)显著高于非感染组(0.36±0.08ng/mL),H=13.338,P<0.01;败血症组hs-CRP水平(23.2±4.7mg/L)显著高于非感染组(3.3±1.2mg/L),H=10.271,P<0.01.恢复期降钙素原、hs-CRP均明显下降,以降钙素原≥0.5ng/mL,hs-CRP≥3mg/L为阳性标准,对诊断新生儿败血症的敏感度分别为94.6%和71.5%,特异度分别为85.2%和63.9%.结论 降钙素原、hs-CRP可作为新生儿败血症的早期检测指标,与hs-CRP相比,降钙素原较其优越性更明显,特别对新生儿重症感染如败血症诊断更有价值.%Objective To explore the value of procalcitonin ( PCT ) and high sensitivity C-reactive protein ( hs-CRP ) in early diagnosis of neonatal septicemia. Methods The level of serum PCT was detected by semi-quantitative solid-phase immune chromatography and the level of serum hs-CRP was determined by immune turbidimetry at admission and recovery stage, and blood was cultured before antibiotic treatment in 146 neonates with septicemia, respectively. The blood samples were
降钙素原和hs-CRP在新生儿败血症诊断中的价值
