西格列汀联合二甲双胍治疗初发2型糖尿病的临床观察
伍华;陈敏;邵丽香;廖爱娇;李晓莉;李卫平;谢乃强
【期刊名称】《中国医药》 【年(卷),期】2013(008)0z1
【摘要】Objective To observe clinical efficacy of sitagliptin phosphate combined with metformin for patients with newly diagnosed type 2 diabetes.Methods All 85 patients with newly diagnosed type 2 diabetes,were divided into sitagliptin group (46 cases)and metformin group(39 cases).The patients in sitagliptin group were treated with sitagliptin(100 mg),and the patients in metformin group were treated with mefformin (500 mg,3 times per day) for 12 weeks.After 12 weeks,all patients were treated with a combination drag therapy for 12 weeks.The fasting blood glucose (FBG),2-hour postprandial blood glucose (2 h BG),glycated hemoglobin (HbA1c),lipids (TG,TC,LDL-C,HDL-C),insulin resistance index (HOMA-IR),and body mass index (BMI) were detected.Results The FBG,2 h BG,HOMA-IR and HbA1c in sitagliptin group and metformin group after treatment for 12 weeks were lower than those before treatment [sitagliptin group:(7.4 ± 1.2) mmol/L vs (9.6 ± 2.4) mmol/L,(9.0 ± 1.4)mmoL/L vs(13.2 ±3.4) mmol/L,(3.2 ±0.5) vs(6.2 ±0.5),(7.1 ±1.1)％ vs(8.7 ±2.5)％ ;mefformin group:(7.3 ±1.1)mmol/L vs(9.5 ±2.5) mmol/L,(8.9 ± 1.5)mmol/L vs(13.6 ±3.2) mmol/L,(3.3 ±0.4)vs (6.0 ± 0.7),(6.7 ± 1.2) ％ vs (8.6 ± 2.6) ％ ; P ＜ 0.05].Mter treatment with
西格列汀联合二甲双胍治疗初发2型糖尿病的临床观察
