子宫颈癌中乳腺癌耐药蛋白mRNA的表达及其临床意义
杨丰美;郭广玲;陈芬;张丽萍;高波
【期刊名称】《肿瘤研究与临床》 【年(卷),期】2013(025)011
【摘要】目的 研究乳腺癌耐药蛋白(BCRP)mRNA在子宫颈癌中的表达及临床意义.方法 实时定量PCR检测12例正常子宫颈组织和47例子宫颈癌组织中BCRP mRNA的表达,并分析其与临床因素间的关系.结果 BCRPmRNA在正常子宫颈组织中低表达,相对表达值为0.19±0.17,在癌组织中高表达,相对表达值为0.59±0.26,两种组织间表达差异有统计学意义(P＜ 0.001).子宫颈癌患者不同临床病理特征之间BCRPmRNA表达差异无统计学意义(P＞0.05).结论 BCRP mRNA在子宫颈癌中高表达,可能参与了子宫颈癌原发性耐药的形成,并且BCRP mRNA表达的检测可能对临床选择化疗方案有一定的指导意义.%Objective To investigate the mRNA expression of breast cancer resistance protein (BCRP) in cervical cancer (CC).Methods The expression of BCRP mRNA was detected by real-time PCR from tissues of 12 normal and 47 cases with CC.Results The expression of BCRP mRNA was 0.59±0.26 in CC and 0.19±0.17 in normal cervical tissues.But it was significantly higher in CC than those in normal tissues (P ＜ 0.05).The expression of BCRP mRNA was not correlated with histological types,tumor differentiation degree and clinical stages (P ＞ 0.05).Conclusion BCRP mRNA over-expresses in CC,wich might play a major role in the intrinsic MDR of CC.Detection of BCRP mRNA
子宫颈癌中乳腺癌耐药蛋白mRNA的表达及其临床意义
