吡格列酮对糖尿病大鼠中枢神经系统PPAR-γ表达的影响
綦雯雯;张京慧;江宏;李佳;石志华;钟历勇
【期刊名称】《神经疾病与精神卫生》 【年(卷),期】2017(017)001
【摘要】Objective To study the effects of pioglitazone on the expressions of peroxisome prolifer-ator-activated receptor-γ (PPAR-γ) in hippocampus and hypothalamus of diabetic rats and to explore the as-sociation between pioglitazone and cognitive function.Methods Thirty male SD rats were equally randomized into control group (C group), diabetic group (D group) and diabetes+pioglitazone group (DP group). The spatial learning and memory function were tested by Morris water maze after 8 weeks. Expressions of PPAR-γ in hippo-campus and hypothalamus were detected by Western Blot.Results In the Morris water maze, escape latencies of D group increased significantly compared to C group and DP group(P<0.05). The expressions of PPAR-γ in hippocampuses and hypothalamuses of D group were significantly lower than C group and DP group(P<0.05). Conclusions Pioglitazone could increase the expressions of PPAR-γ in hippocampus and hypothalamus of dia-betic rats, which may be related to the improvement of spatial learning and memory function caused by pioglita-zone.%目的 研究吡格列酮对糖尿病大鼠海马、下丘脑处PPAR-γ表达的影响及与大鼠认知功能的关系.方法 雄性SD大鼠随机分为对照组(C组)、
吡格列酮对糖尿病大鼠中枢神经系统PPAR-γ表达的影响
