辛伐他汀对脂多糖诱导帕金森病大鼠多巴胺神经元损伤的
保护作用
王埮;唐北沙;曹学兵;陈志斌;陈小武;黄培培;张填
【期刊名称】《中华行为医学与脑科学杂志》 【年(卷),期】2015(024)003
【摘要】Objective To examine the effect of simvastatin treatment on Parkinson's disease rats induced by lipopolysaccharide (LPS) and its mechanism.Methods The LPS-PD model was established by injection of LPS (5 mg/mL) into the right substantia nigra compacta (SNC),and rats were randomly divided into control group,LPS-model group and simvastatin treatment group with 15 rats in each group.Rats in the simvastatin treatment group was intraperitoneally administered simvastatin (5 mg/kg) before,and daily for 14 days after surgery,while the control group and LPS-model group received same volume normal saline and LPS respectively.Ionized calcium binding adaptor molecule 1 (Iba-1)-positive cells and the expression of tyrosine hydroxylase (TH),tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the SNC were detected by immunohistochemistry,Western blotting and enzyme-linked
immunosorbent
assay,respectively.The
effect
of
simvastatin in the PD model was also examined in behavioral tests.Results The LPS-model group exhibited typical animal PD behaviors.Compared with the control group,the LPS-model group
辛伐他汀对脂多糖诱导帕金森病大鼠多巴胺神经元损伤的保护作用
