nm23-H1及热休克蛋白27在非小细胞肺癌中的表达及临
床意义
薛兴阳;赵健;周明;赵光日;傅文凡;杨嵘皓;孟江
【期刊名称】《肿瘤研究与临床》 【年(卷),期】2013(025)004
【摘要】目的 分析nm23-H1和热休克蛋白27(HSP27)在非小细胞肺癌(NSCLC)发生、发展及转移中的作用.方法 应用免疫组织化学法检测75例NSCLC组织及28例良性肺病变中nm23-H1和HSP27的表达情况,并将检测结果与临床病理特征进行综合分析.结果 nm23-H1和HSP27的表达主要定位于细胞质,nm23-H1和HSP27在NSCLC中表达的阳性率分别为41.3 %(31/75)和80.0%(60/75),明显高于良性肺病变7.1%(2/28)和46.4%(13/28)(x2=10.946,P=0.001;x2=11.131,P=0.001).NSCLC中HSP27蛋白的表达与肿瘤分化程度密切相关(x2 =4.191,P=0.041).肺癌组织中nm23-H1、HSP27的表达水平有相关性(r=0.284,P=0.013).结论 nm23-H1、HSP27与NSCLC的发生、发展有关,二者联合检测对肺癌的诊断和生物学行为判断有一定的意义.%Objective To detect the expressions of nm23-H1 and heat shock protein 27 (HSP27) and their clinical significance on development and metastasis in non-small cell lung carcinoma (NSCLC).Methods 75 tumor tissues from patients with NSCLC were included as experimental group and 28 pulmonary benign lesion tissues were as control group.The expressions of nm23-H1 and HSP27 in patients with different clinical
and
pathological
characters
were
detected
by
immunohistochemistry.Results nm23-H1 and HSP27 were mainly expressed in cytoplasm,the positive rates of nm23-H1 and HSP27 were significantly higher in the experimental group than that in control group [41.3 % (31/75) vs 7.1% (2/28),x2 =10.946,P =0.001,80.0 % (60/75) vs 46.4 % (13/28),x2 =11.131,P =0.001].Compared with control group,the positive rate of HSP27 was correlated with the degree of tumor differentiation (x2 =4.191,P =0.041).nm23-H1 was related with HSP27 in lung cancer (r =0.284,P =0.013).Conclusion nm23-H1 and HSP27 are related to the occurrence and development of NSCLC.The joint detection of nm23-H1 and HSP27 should be helpful to the diagnosis and judge the biological behavior of NSCLC. 【总页数】3页(217-219)
【关键词】癌,非小细胞肺;免疫组织化学;nm23-H1;热休克蛋白27 【作者】薛兴阳;赵健;周明;赵光日;傅文凡;杨嵘皓;孟江
【作者单位】510095 广州医学院附属肿瘤医院胸外科;510095 广州医学院附属肿瘤医院胸外科;510095 广州医学院附属肿瘤医院胸外科;510095 广州医学院附属肿瘤医院胸外科;510095 广州医学院附属肿瘤医院胸外科;510095 广州医学院附属肿瘤医院胸外科;广东药学院中药学院中药制药系 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_cancer-
research-clinic_thesis/0201236874345.html 【相关文献】
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nm23-H1及热休克蛋白27在非小细胞肺癌中的表达及临床意义
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