Evaluation of weight reduction and anti-cholesterol activity of Punarnava root extract aga

Evaluation of weight reduction and anti-cholesterol activity of Punarnava root extract against high fat diets induced obesity in experimental rodent

Mohammad Khalid;H H Siddiqui

【期刊名称】《亚太热带生物医学杂志（英文版）》 【年(卷),期】2012(000)0z3

【摘要】Objective: To evaluate the weight reduction and hypercholesteremic potential of punarnava root extract induced with high fat diets in experimental rodents by administrating oral doses (100, 200 and 400 mg/kg). Methods: Thirty six female Sprague-Dawley rats were divided in six groups and each group had six animals. Group-I administered laboratory diet, control obese group-II induced with high fat diet (HFD), group-III standard drug plus HFD rats (5 mg/kg) and Boerhaavia diffusa root extract (BDRE) were administered (100, 200 and 400 mg/kg) plus HFD rats (group-IV, V and VI). After the end of experimental period (60 days) the body weight, organ fat pad weight, lipid profile, liver and kidney marker enzyme were estimated along with histopathological examination in experimental groups of animals. Results: The obtained results showed that the significant reduction on administration of BDRE (200 and 400 mg/kg) in body weight, visceral fat pad (P<0.01- ), lipids level (P<0.01), AST and ALT (P<0.01), urea (P<0.01) and creatinine (P<0.01) when compared with HFD groups II. The

biochemical estimation were supplemented by histopathological examinations. Conclusions: The results of this study scientifically supported its traditional uses of Boerhaaviadiffusa as antiobesity activity by normalizes the elevated body weight and organ fat pad weight as well as antilipidemic property by lowering the altered levels of lipid profile in female Sprague-Dawley. 【总页数】6页(1323-1328) 【关键词】

【作者】Mohammad Khalid;H H Siddiqui

【作者单位】Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Integral University, Lucknow Uttar Pradesh 226026;Department of Pharmacology and toxicology, Faculty of Pharmacy, Integral University, Lucknow Uttar Pradesh 226026 【正文语种】英文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_asia-pacific-tropical-biomedical-journal-english_thesis/0201254093326.html 【相关文献】

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