Treatment of Hodgkin's Disease with Chemotherapy Based- Regimens： Long-term Follow-up

Treatment of Hodgkin＇s Disease with Chemotherapy Based- Regimens： Long-term

Follow-up Results with 295 Patients

HuiqiangHuang;QingqingCai;XubingLin;YuhongLi;GuangchuanXu;LiZhang;YouiianHe;XiaofeiSun;ZongmeiZhou;DonggangLiu;RuihuoXu;TongyuLin;XiaoyuTeng;MaozhenLiu;YisunSu;WenqiJiang;ZhongzhenGuang

【期刊名称】《中国肿瘤临床：英文版》 【年(卷),期】2004(001)003

【摘要】OBJECTIVE Hodgkin's disease (HD) is a chemo and radio-sensitive hematologic malignancy. At the present time, improvement of its cure rate, reduction of its long-term detrimental effects, and maintenance of a good quality of life are the major concerns in the treatment of HD. In this study the results of a long -term follow-up from our cancer center was analyzed retrospectively in terms of efficacy and collateral side effects. METHODS The results were analyzed for 295 patients with histologicallyverified HD who were treated from 1970 to 2000, especially 182 patients treated from 1980 to 2000. Multivariant analysis (COX model ) was employed to elucidate the prognostic determinants. RESULTS The 5, 10 and 20-year survival for 295 patients with HD were 63.5%, 55.8% and 47.1% respectively with a median survival time of 172 months (28-352 months ). The median follow-up time was 43 months (17-352 months). The 5, 10 and 20 years overall