Current and Future Clinical Applications of Zinc Transporter-8 in Type 1 Diabetes Mellitus

Current and Future Clinical Applications of Zinc

Transporter-8 in Type 1 Diabetes Mellitus

Bo Yi;Gan Huang;Zhi-Guang Zhou

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2015(128)017

【摘要】Objective:To evaluate the utility of zinc transporter-8 (ZnT8) in the improvement of type 1 diabetes mellitus (T1DM) diagnosis and prediction,and to explore whether ZnT8 is a potential therapeutic target in T l DM.Data Sources:A search was conducted within the medical database PubMed for relevant articles published from 2001 to 2015.The search terms are as follows:\\1 diabetes,\\autoimmune

diabetes

in

adults,\

\

2

diabetes,\

\

autoantibodies,\We also searched the reference lists of selected articles.Study Selection:English-language original articles and critical reviews concerning ZnT8 and the clinical applications of islet autoantibodies in diabetes were reviewed.Results:The basic function of ZnT8 is maintaining intracellular zinc homeostasis,which modulates the process of insulin biosynthesis,storage,and secretion.Autoantibodies against ZnT8 (ZnT8A) and ZnT8-specific T cells are the reliable biomarkers for the

identification,stratification,and

characterization

ofTl

DM.Additionally,the results from the animal models and clinical trials