Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carc
Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against
hydrogen peroxide
Garg;Neeraj;K;Mangal;Sharad;Sahu;Tejram;Mehta;Abhinav;Vyas;Suresh;P;Tyagi;Rajeev;K;;;;;;;;
【期刊名称】《亚太热带生物医学杂志:英文版》 【年(卷),期】2011(000)001
【摘要】Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric
acid,salicylic
acid,and
estimate
H2O2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was investigated.H2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability(%apoptosis),nucleosomal damage and DNA fragmentation, bcl-2 levels
and
flow
cytometery
analysis
(
ROS
production
evaluation).Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were investigated.It was observed that these antioxidants had protective effect(anti-apoptotic activity) against hydrogen peroxide(H2O2) in renal cell carcinoma(RCC-26) cell line.Conclusions:This study reveals and
Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carc
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