光纤传感技术快速定量分析复方卡托普利片
李莉;李思栋;孙颖平;孙晓伟
【期刊名称】《中国现代应用药学》 【年(卷),期】2013(030)007
【摘要】OBJECTIVE To establish a rapid analysis method of compound Catoporile tablets by optical-fiber sensing technology and UV dual wavelength spectrum.METHODS Under optical-fiber sensing system,the probe was inserted into sample dissolution,the characteristic map of the sample was obtained instantaneously,it could be stored in the sample database by software with the standard map in standard map database for comparation.Under the difference of characteristic parameters and the method of UV dual wavelength,the excipients interference and the mutual interference between the effective component could be deducted by computer software.Adopting reference substance comparation method,quantitative analysis of the effective component such as catoporile and hydrochlorothiazide could be achieved rapidly.RESULTS Determination of this method did not need to filter excipients,the treatment of sample was simple.The linear correlation coefficients of the content determination of hydrochlorothiazide and catoporil were 0.999 8 and 0.999 6,and the average recovery are 100.2％ and 100.6％.The results were in line with Ch.P in the regulations.CONCLUSION The method of analysis by fiber optic sensor
光纤传感技术快速定量分析复方卡托普利片
