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Inhibitors?Agonists?Screening Librarieswww.MedChemExpress.cnUngeremineCat. No.:CAS No.:HY-N19712121-12-2C??H??NO?266.27Topoisomerase; Caspase; Ferroptosis; AutophagyCell Cycle/DNA Damage; Apoptosis; AutophagyPlease store the product under the recommended conditions in the COA.分?式:分?量:作?靶点:作?通路:储存?式:BIOLOGICAL ACTIVITY?物活性Ungeremine，?种从 Pancratium Illyricum 提取的菲啶类?物碱。Ungeremine 有效地靶向哺乳动物以及细菌的 I 型和 II 型拓扑异构酶。Ungeremine 对 9 种癌细胞系表现出细胞毒活性，包括药物敏感性和 MDR 表型。Ungeremine 诱导铁营养症、坏死、?噬以及caspase激活介导的细胞凋亡、MMP 改变和 ROS ?成增加。 REFERENCES[1]. Casu L, et al. Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.[2]. Mbaveng A, et al. Cytotoxicity of ungeremine towards multi-factorial drug resistant cancer cells and induction of apoptosis, ferroptosis, necroptosis and autophagy. Phytomedicine. 2019 Jul;60:152832.McePdfHeightCaution: Product has not been fully validated for medical applications.
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