Direct and Indirect Role of Toll-Like Receptors in T Cell Mediated Immunity

Direct and Indirect Role of Toll-Like Receptors in T

Cell Mediated Immunity

DamoXu;HaiyingLiu;MousaKomai-Koma

【期刊名称】《细胞与分子免疫学：英文版》 【年(卷),期】2004(001)004

【摘要】Toll-like receptors (TLR) are pathogen-associated molecular patterns (PAMPs) recognition receptors that play an important role in protective immunity against infection and inflammation. They act as central integrators of a wide variety of signals, responding to diverse agonists of microbial products. Stimulation of Toll-like receptors by microbial products leads to signaling pathways that activate not only innate, but also adaptive immunity by APC dependent or independent mechanisms. Recent evidence revealed that TLR signals played a determining role in the skewing of naive T cells towards either Thl or Th2 responses. Activation of Toll-like receptors also directly or indirectly influences regulatory T cell functions. Therefore, TLRs are required in both immune activation and immune regulation. Study of TLRs has significantly enhanced our understanding of innate and adaptive immune responses and provides novel therapeutic approaches against infectious and inflammatory diseases. Cellular & Molecular Immunology. 【总页数】8页(239-246)

【关键词】TLR;受体;T细胞间接免疫;PAMPs;病原体;Thl;Th2;获得性免疫

【作者】DamoXu;HaiyingLiu;MousaKomai-Koma 【

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DivisionofImmunology,InfectionandInflammation,UniversityofGlasgow,Glasgow,G116NT,UK 【正文语种】英文 【中图分类】R392 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_cellular-molecular-immunology_thesis/0201223969459.html 【相关文献】

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